{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:57:36Z","timestamp":1789559856706,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Irreversible electroporation (IRE) is a non\u2010thermal focal therapy that utilizes high voltage electric pulses to permanently rupture the cellular membrane and induce cell death. In this multi\u2010center study, we evaluated the safety and efficacy of IRE in patients with locally advanced pancreatic cancer (LAPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2012 to 2015, we performed laparotomic and laparoscopic IRE in a total of 70 patients with stage III LAPC. Either gemcitabine\u2010based or TS\u20101 (Tegafur, Gimeracil, and Oteracil) chemotherapy was applied for at least 3 months before the IRE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No IRE\u2010related deaths occurred. A median follow\u2010up of 28.1 months showed that six patients (8.6%) experienced local recurrence and 24 (34%) experienced distant progression. The overall median survival from the time of treatment was 22.6 months, and the progression\u2010free survival (PFS) was 15.4 months. The overall survival in the patients who used gemcitabine\u2010based reagents was 19.1 months and that of those who used TS\u20101 was 28.7 months. The PFS for these two groups were 13.2 months and 26.4 months; the difference is significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that IRE is safe and effective for the control of LAPC. We surmise that the addition of IRE to a chemotherapy regimen may provide a survival advantage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25110","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T14:25:05Z","timestamp":1528381505000},"page":"31-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The efficacy of combination of induction chemotherapy and irreversible electroporation ablation for patients with locally advanced pancreatic adenocarcinoma"],"prefix":"10.1002","volume":"118","author":[{"given":"Kai\u2010Wen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Surgery and Hepatitis Research Center National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5828-8615","authenticated-orcid":false,"given":"Po\u2010Chih","family":"Yang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Center for Organ Transplantation and Liver Disease Treatment Fu Jen Catholic University Hospital New Taipei City Taiwan"},{"name":"School of Medicine Fu Jen Catholic University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uei","family":"Pua","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Tan Tock Seng Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010Deuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute of Radiological Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-4078","authenticated-orcid":false,"given":"Sheng\u2010Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Oncology Cancer Center Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Dong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Qiang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Tianjin Medical University Cancer Institute and Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Chin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.06.058"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-6-612"},{"key":"e_1_2_10_4_1","unstructured":"Taiwan Cancer Registry. Incidence and mortality rates for the top 10 cancer in Taiwan. Cancer statistics.2011.http:\/\/tcr.cph.ntu.edu.tw\/main.php?Page\u2009=\u2009N2. Accessed January 30 2018."},{"key":"e_1_2_10_5_1","first-page":"39","article-title":"Irreversible electroporation in the treatment of locally advanced pancreas and liver metastases of colorectal carcinoma","volume":"20","author":"Wichtowski M","year":"2016","journal-title":"Contemp Oncol (Pozn)"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2006.873745"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181d27b30"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1532\/HSF98.20061202"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/153303460700600407"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21899"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.22786"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001441"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.01.024"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2016.10.023"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375323"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-017-0887-4"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T07:17:55Z","timestamp":1694330275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,7]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/jso.25110"],"URL":"https:\/\/doi.org\/10.1002\/jso.25110","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,7]]},"assertion":[{"value":"2018-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}