{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:09:02Z","timestamp":1768536542368,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Gastrointestinal stromal tumors (GIST) are the most common sarcoma arising from the gastrointestinal tract. Data regrading long\u2010term prognosis based on tumor location (stomach vs small intestine) are mixed, so we aimed to analyze their outcomes using a large national oncology database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Cancer Database was queried for cases of stomach and small intestine GIST between the years 2004 and 2014. Survival analysis was performed using the Kaplan\u2010Meier method, and factors related to survival were compared using the Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 18\u2009900 total patients, those with small intestine GIST had larger median tumor size (6.2\u2009cm; interquartile range [IQR], 3.8 to 10.0 vs stomach: 5.0\u2009cm; IQR, 3.0 to 9.0; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and a higher incidence of tumors with \u22655\u2009mitoses\/50\u2009HPF (29.3% vs stomach: 24.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Unadjusted median overall survival (OS) was longer for patients with stomach GIST (10.3 years) as compared to small intestine GIST (9.4 years) (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). After controlling for patient and tumor\u2010related factors, however, OS did not differ between stomach and small intestine GIST (hazard ratio, 1.19; 95% confidence interval, 0.88 to 1.61; <jats:italic>P<\/jats:italic>\u2009=\u20090.26).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with small intestine GIST more commonly have larger, high mitotic rate tumors, but despite these worse prognostic features, tumor location did not independently impact OS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25172","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:45:39Z","timestamp":1534952739000},"page":"486-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparing the long\u2010term outcomes among patients with stomach and small intestine gastrointestinal stromal tumors: An analysis of the National Cancer Database"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-1854","authenticated-orcid":false,"given":"Katherine","family":"Giuliano","sequence":"first","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aslam","family":"Ejaz","sequence":"additional","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley N.","family":"Reames","sequence":"additional","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WonSeok","family":"Choi","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine &amp; Health Sciences Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Sham","sequence":"additional","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Gage","sequence":"additional","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2794-7179","authenticated-orcid":false,"given":"Fabian M.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nita","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"issue":"4","key":"e_1_2_6_1_2_1","first-page":"1293","article-title":"Biological and clinical review of stromal tumors in the gastrointestinal tract","volume":"15","author":"Nishida T","year":"2000","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0116"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21167"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20862"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000146010.92933.de"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-008-0798-7"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi127"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds252"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2012.0099"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60500-6"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.347"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020461"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.0183"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70222-9"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.123545"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2006.09.001"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70242-6"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.06.025"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23199"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0571-3"},{"key":"e_1_2_6_1_22_1","unstructured":"The American Cancer Society and the Commission on Cancer of the American College of Surgeons. 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