{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:28:14Z","timestamp":1792124894331,"version":"4.4.0"},"reference-count":100,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although surgical and medical treatment options are available for the treatment of chronic lymphedema, there is no cure. Recent advances in microsurgery have provided an opportunity to perform immediate lymphatic reconstruction after lymphadenectomy for disease prevention. In this review, we provide the historical background leading to a paradigm shift in performing this procedure. We will also discuss the current evidence for immediate lymphatic reconstruction, potential oncologic procedures amenable to this approach, and detail ongoing challenges.<\/jats:p>","DOI":"10.1002\/jso.25177","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T18:45:13Z","timestamp":1534445113000},"page":"750-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Immediate lymphatic reconstruction"],"prefix":"10.1002","volume":"118","author":[{"given":"Anna Rose","family":"Johnson","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-1647","authenticated-orcid":false,"given":"Dhruv","family":"Singhal","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,16]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1413.014"},{"key":"e_1_2_11_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3510"},{"key":"e_1_2_11_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4801.2005.00066.x"},{"key":"e_1_2_11_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-012-0247-5"},{"key":"e_1_2_11_1_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2011.0011"},{"key":"e_1_2_11_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002683"},{"key":"e_1_2_11_1_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.29033.sr"},{"key":"e_1_2_11_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2017.08.001"},{"key":"e_1_2_11_1_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"e_1_2_11_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70076-7"},{"key":"e_1_2_11_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002337"},{"key":"e_1_2_11_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.11.1253"},{"key":"e_1_2_11_1_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.3517"},{"key":"e_1_2_11_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25458"},{"key":"e_1_2_11_1_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.04.017"},{"key":"e_1_2_11_1_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.09.018"},{"key":"e_1_2_11_1_18_1","first-page":"1","article-title":"Prospective evaluation of a prevention protocol for lymphedema following surgery for breast cancer","volume":"42","author":"Boccardo FM","year":"2009","journal-title":"Lymphology"},{"key":"e_1_2_11_1_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016591121762"},{"key":"e_1_2_11_1_20_1","article-title":"A lymphedema surveillance program for breast cancer patients reveals the promise of surgical prevention","author":"Hahamoff M","year":"2017","journal-title":"J Surg Res"},{"key":"e_1_2_11_1_21_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20100167"},{"key":"e_1_2_11_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23494"},{"key":"e_1_2_11_1_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000010"},{"key":"e_1_2_11_1_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000597"},{"key":"e_1_2_11_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2012.12.007"},{"key":"e_1_2_11_1_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503143121101"},{"key":"e_1_2_11_1_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903303201302"},{"key":"e_1_2_11_1_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511303332203"},{"key":"e_1_2_11_1_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022152"},{"key":"e_1_2_11_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.10.215"},{"key":"e_1_2_11_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.12.011"},{"key":"e_1_2_11_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70460-7"},{"key":"e_1_2_11_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70166-9"},{"key":"e_1_2_11_1_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.90"},{"key":"e_1_2_11_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70207-2"},{"key":"e_1_2_11_1_36_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0452-2"},{"key":"e_1_2_11_1_37_1","first-page":"81","article-title":"Presence of functional axillary lymph nodes and lymph drainage within arms in women with and without breast cancer\u2010related lymphedema","volume":"40","author":"Szuba A","year":"2007","journal-title":"Lymphology"},{"key":"e_1_2_11_1_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/1677-5449.0040"},{"key":"e_1_2_11_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000201)88:3<608::AID-CNCR17>3.0.CO;2-K"},{"key":"e_1_2_11_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02574496"},{"key":"e_1_2_11_1_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.5.482"},{"key":"e_1_2_11_1_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001778"},{"key":"e_1_2_11_1_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3725"},{"key":"e_1_2_11_1_44_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9412-x"},{"key":"e_1_2_11_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.05.011"},{"key":"e_1_2_11_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.06.008"},{"key":"e_1_2_11_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.12.022"},{"key":"e_1_2_11_1_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150285"},{"key":"e_1_2_11_1_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25096"},{"key":"e_1_2_11_1_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10041"},{"key":"e_1_2_11_1_51_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0554-x"},{"key":"e_1_2_11_1_52_1","first-page":"1","article-title":"The studies on lymphatic venous anastomosis in lymphedema","volume":"32","author":"Yamada Y","year":"1969","journal-title":"Nagoya J Med Sci"},{"key":"e_1_2_11_1_53_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0270-y"},{"key":"e_1_2_11_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22254"},{"key":"e_1_2_11_1_55_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4721-y"},{"key":"e_1_2_11_1_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001034"},{"key":"e_1_2_11_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.020"},{"key":"e_1_2_11_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)00302-L"},{"key":"e_1_2_11_1_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23084"},{"key":"e_1_2_11_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.03.019"},{"key":"e_1_2_11_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830601)51:11<2152::AID-CNCR2820511134>3.0.CO;2-7"},{"key":"e_1_2_11_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800731119"},{"key":"e_1_2_11_1_63_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5790"},{"key":"e_1_2_11_1_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0004-8666.2003.00040.x"},{"key":"e_1_2_11_1_65_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21253"},{"key":"e_1_2_11_1_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22684"},{"key":"e_1_2_11_1_67_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/341253"},{"key":"e_1_2_11_1_68_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.2528"},{"key":"e_1_2_11_1_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.0566"},{"key":"e_1_2_11_1_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e318287a8e8"},{"key":"e_1_2_11_1_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.06.004"},{"key":"e_1_2_11_1_72_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2003.13304.x"},{"key":"e_1_2_11_1_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.07.007"},{"key":"e_1_2_11_1_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000222727.05869.04"},{"key":"e_1_2_11_1_75_1","first-page":"4005","article-title":"Lower body lymphedema in patients with gynecologic cancer","volume":"37","author":"Biglia N","year":"2017","journal-title":"Anticancer Res"},{"key":"e_1_2_11_1_76_1","first-page":"814","article-title":"A model of chronic postsurgical lymphedema in dogs\u2019 limbs","volume":"64","author":"Danese CA","year":"1968","journal-title":"Surgery"},{"key":"e_1_2_11_1_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181f44658"},{"key":"e_1_2_11_1_78_1","doi-asserted-by":"publisher","DOI":"10.5758\/kjves.2011.27.3.114"},{"key":"e_1_2_11_1_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199004000-00012"},{"key":"e_1_2_11_1_80_1","doi-asserted-by":"publisher","DOI":"10.1159\/000194273"},{"key":"e_1_2_11_1_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001460"},{"key":"e_1_2_11_1_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920040408"},{"key":"e_1_2_11_1_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2017.08.029"},{"key":"e_1_2_11_1_84_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1635116"},{"key":"e_1_2_11_1_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.02.031"},{"key":"e_1_2_11_1_86_1","first-page":"10","article-title":"Lymphangiogenesis and lymphangiogenic growth factors","volume":"32","author":"Hartiala P","year":"2016","journal-title":"J Reconstr Microsurg"},{"key":"e_1_2_11_1_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00535.2009"},{"key":"e_1_2_11_1_88_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.84095"},{"key":"e_1_2_11_1_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal3920"},{"key":"e_1_2_11_1_90_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034008"},{"key":"e_1_2_11_1_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2638"},{"key":"e_1_2_11_1_92_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2011.0024"},{"key":"e_1_2_11_1_93_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2303"},{"key":"e_1_2_11_1_94_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060164"},{"key":"e_1_2_11_1_95_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2008.1524"},{"key":"e_1_2_11_1_96_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1206230"},{"key":"e_1_2_11_1_97_1","unstructured":"American Cancer Society. Women's Health and Cancer Rights Act: The Federal Law [Internet]. 2014 [cited 2018 Jun 12]. Available from:https:\/\/www.cancer.org\/treatment\/finding\u2010and\u2010paying\u2010for\u2010treatment\/understanding\u2010health\u2010insurance\/health\u2010insurance\u2010laws\/womens\u2010health\u2010and\u2010cancer\u2010rights\u2010act.html"},{"key":"e_1_2_11_1_98_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.231"},{"key":"e_1_2_11_1_99_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2013.0004"},{"key":"e_1_2_11_1_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2009.00855.x"},{"key":"e_1_2_11_1_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010915)92:6<1368::AID-CNCR1459>3.0.CO;2-9"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.25177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T02:12:06Z","timestamp":1694225526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,16]]},"references-count":100,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/jso.25177"],"URL":"https:\/\/doi.org\/10.1002\/jso.25177","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,16]]},"assertion":[{"value":"2018-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}