{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:20:42Z","timestamp":1777353642205,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science and Technology Major Special Project","award":["2012ZX10002010001009"],"award-info":[{"award-number":["2012ZX10002010001009"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Assessing hepatic functional reserve before hepatectomy is beneficial to reduce the incidence of posthepatectomy liver failure (PHLF). This study aimed to compare the ability of the Child\u2010Pugh score, model for end\u2010stage liver disease (MELD) score, and retention test at 15\u2009minutes (indocyanine green [ICG]\u2010R15) to assess hepatic functional reserve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 185 patients with hepatocellular carcinoma (HCC) undergoing hepatectomy were enrolled in this study. The ability of Child\u2010Pugh score, MELD score, and ICG\u2010R15 predicting severe\u00a0PHLF were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 23 patients (12.4%) developed severe PHLF. Multivariate analyses identified that platelet count, ICG\u2010R15, clinically significant portal hypertension, and major resection were independent factors for predicting severe PHLF. The area under the receiver operating characteristic curve of ICG\u2010R15 for predicting severe PHLF was higher than that of both Child\u2010Pugh score and MELD score. With an optimal cutoff\u00a0value of 7.1%, the sensitivity and specificity of ICG\u2010R15 for predicting severe PHLF were 52.2% and 89.5%, respectively. Both the incidence of severe PHLF and mortality in patients with ICG\u2010R15 &gt;7.1% were significantly higher than the figures for patients with ICG\u2010R15 \u22647.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICG\u2010R15 is more accurate than the Child\u2010Pugh score and MELD score in predicting hepatic functional reserve before hepatectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25184","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T07:20:54Z","timestamp":1601364054000},"page":"440-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Comparison of the ability of Child\u2010Pugh score, MELD score, and ICG\u2010R15 to assess preoperative hepatic functional reserve in patients with hepatocellular carcinoma"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6170-0487","authenticated-orcid":false,"given":"Yan\u2010Yan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China"},{"name":"Hepatopancreatobiliary Surgery Department I Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Zhou","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei\u2010Xiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Mei","family":"You","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bang\u2010De","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le\u2010Qun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60009-9"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61347-0"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000236"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068193"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10095"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.10.001"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.11.015"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.9151"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5852"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104072"},{"key":"e_1_2_6_1_12_1","first-page":"H953","article-title":"Hepatic plasma flow: accuracy of estimation from bolus injections of indocyanine green","volume":"252","author":"Burczynski FJ","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(03)00224-X"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/110241599750006686"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27431"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000611"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26700"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T08:46:18Z","timestamp":1694940378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/jso.25184"],"URL":"https:\/\/doi.org\/10.1002\/jso.25184","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"2018-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}