{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:59:30Z","timestamp":1772575170832,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Identifying factors associated with nonsentinel lymph node (NSN) metastases in melanoma patients with a single positive sentinel lymph node (SLN) could aid decision making regarding adjuvant therapy. We describe a model for identifying patients with a single positive SLN at low risk for NSN metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Factors associated with NSN metastasis in patients with a primary cutaneous melanoma and a single positive SLN who underwent completion lymph node dissection (CLND) were identified. These factors were used to construct a model for predicting the NSN status. The model was validated using a separate data set from another tertiary referral cancer center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the training data set, 111 patients had a single positive SLN. Of these, 27 had positive NSN. SLN tumor deposit diameter \u22650.75\u2009mm (OR, 3.43; <jats:italic>P<\/jats:italic>\u2009=\u20090.047), age \u226540 (OR, 12.14; <jats:italic>P<\/jats:italic>\u2009=\u20090.024), and multifocal SLN tumor deposit location (OR, 4.16; <jats:italic>P<\/jats:italic>\u2009=\u20090.0096) were independently associated with NSN positivity. Patients with 0 to 1 of these risk factors had a low risk of NSN metastasis in both the training (7.5%) and validation (4.6%) data sets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A combination of patient and SLN tumor burden characteristics can help to identify patients with a single positive SLN who are at a low risk of NSN metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25193","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T08:29:49Z","timestamp":1538036989000},"page":"922-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A model for predicting low probability of nonsentinel lymph node positivity in melanoma patients with a single positive sentinel lymph node"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-2788","authenticated-orcid":false,"given":"Neal","family":"Bhutiani","sequence":"first","affiliation":[{"name":"Department of Surgery University of Louisville  Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Egger","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Louisville  Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold J.","family":"Stromberg","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey E.","family":"Gershenwald","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrick I.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prejesh","family":"\u00a0Philips","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Louisville  Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5537-3387","authenticated-orcid":false,"suffix":"II","given":"Robert C. 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