{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:39:58Z","timestamp":1774471198867,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T00:00:00Z","timestamp":1535846400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The safety of laparoscopic resection of very large pheochromocytomas is unclear, and preoperative preparation may benefit from refinement. This retrospective study was designed to determine the correlation between tumor size and perioperative characteristics by evaluating data from patients who underwent laparoscopic resection of pheochromocytomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 253 patients were grouped according to their tumor diameter: diameter \u22658\u2009cm, Glarge (G<jats:sub>lg<\/jats:sub>) (<jats:italic>n<\/jats:italic>\u2009=\u200930); diameter 6 to 8\u2009cm, Gmedium (G<jats:sub>md<\/jats:sub>) (<jats:italic>n<\/jats:italic>\u2009=\u200957); and diameter &lt;6\u2009cm, Gsmall (G<jats:sub>sm<\/jats:sub>) (<jats:italic>n<\/jats:italic>\u2009=\u2009166). The perioperative data were compared among the three groups using the analysis of variance test, Wilcoxon\u2019s rank\u2010sum test, and the chi\u2010square test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the G<jats:sub>lg<\/jats:sub> and G<jats:sub>md<\/jats:sub> groups had a higher preoperative phenoxybenzamine daily dose and 24\u2010hour urine levels of noradrenaline and adrenaline than those in the G<jats:sub>sm<\/jats:sub> group, as they needed longer vasopressor support. Transfusion of allogeneic blood products was found to be increased in\u00a0patients of the G<jats:sub>lg<\/jats:sub> group compared with the other two groups\u00a0and their intensive care unit stays were longer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with small\u2010sized pheochromocytomas, laparoscopic resection of medium\u2010sized pheochromocytomas requires vigilant monitoring and resolution of hemodynamic fluctuations. Patients with very large pheochromocytomas are at greater risk of intraoperative bleeding and may benefit from the ensured availability of blood products and intensive postoperative monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25205","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T04:18:18Z","timestamp":1535948298000},"page":"709-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Perioperative management during laparoscopic resection of large pheochromocytomas: A single\u2010institution retrospective study"],"prefix":"10.1002","volume":"118","author":[{"given":"Hongju","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Jiujiang Maternal and Child Care Centres  Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-0910","authenticated-orcid":false,"given":"Xuerong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,2]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2005.01199.x"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62884-2"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.07.008"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.10.012"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-003-8827-0"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.4293\/108680812X13291597715862"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2014.09076"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689910094"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP12014.OR"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1397-z"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2016.08.10"},{"key":"e_1_2_9_1_13_1","first-page":"471","article-title":"Laparoscopic treatment of pheochromocytomas smaller of larger than 6 cm","volume":"84","author":"Conzo G","year":"2013","journal-title":"Ann Ital Chir"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2015.52869"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.12.019"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-015-4643-6"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.6.768"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000253816.83011.DB"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T05:30:48Z","timestamp":1694928648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/jso.25205"],"URL":"https:\/\/doi.org\/10.1002\/jso.25205","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"2018-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}