{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:14:16Z","timestamp":1770120856694,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"LMK foundation"},{"name":"Hudfonden"},{"name":"S.R. Gorthon foundation"},{"name":"Australian National Health and Medical Research Council"},{"name":"Swedish National Health Services"},{"name":"M. Paulsson Fund"},{"name":"S. Paulsson Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sentinel lymph node (SLN) metastasis in patients with thin melanomas (\u22641\u2009mm) is uncommon but adverse prognostic factors may indicate an increased risk. We sought to determine how often SLN biopsy (SLNB) was performed in patients with thin melanomas, establish the frequency of SLN metastasis and evaluate the predictive value of ulceration, tumor mitotic rate, and thickness for SLN involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Melanoma patients with a Breslow thickness\u00a0greater than or equal to 0.5 to less than or equal to 1\u2009mm, diagnosed 2009\u20102016, were identified in the Swedish Melanoma Register (SMR) and the Melanoma Institute Australia (MIA) Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total 8165 patients were included from the SMR and 1603 from MIA. SLNB was performed in 9.5% and 16.2% of patients, respectively. Corresponding figures for T1b (<jats:italic>American Joint Committee on Cancer<\/jats:italic> [AJCC] 7th Edition) were 19.5% and 24.6%. The SLN positivity rate were 4.4% (Sweden) and 5.8% (MIA). SLN metastasis was more frequent in tumors with ulceration, mitoses, and Breslow thickness greater than or equal to 0.9\u2009mm but none were statistically significant. Younger age was identified as a significant risk factor for SLN positivity at MIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A minority of patients with thin melanomas had SLNB performed and the SLN positivity rate was low. This study did not confirm tumor ulceration, mitoses, or thickness as statistically significant predictors for SLN metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25208","type":"journal-article","created":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T16:49:17Z","timestamp":1536511757000},"page":"599-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sentinel lymph node biopsy in patients with thin melanomas: Frequency and predictors of metastasis based on analysis of two large international cohorts"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3690-5680","authenticated-orcid":false,"given":"Karolin","family":"Isaksson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Surgery Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Dermatology Lund University, Helsingborg Hospital Helsingborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasmus","family":"Mikiver","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Regional Cancer Center South East Sweden, Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omgo E.","family":"Nieweg","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia, The University of Sydney Sydney New South Wales Australia"},{"name":"Sydney Medical School, The University of Sydney Sydney New South Wales Australia"},{"name":"Departments of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia, The University of Sydney Sydney New South Wales Australia"},{"name":"Sydney Medical School, The University of Sydney Sydney New South Wales Australia"},{"name":"Departments of Tissue Pathology and Diagnostic Oncolocy, Royal Prince Alfred Hospital Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia, The University of Sydney Sydney New South Wales Australia"},{"name":"Sydney Medical School, The University of Sydney Sydney New South Wales Australia"},{"name":"Departments of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ingvar","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Surgery Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,9]]},"reference":[{"key":"e_1_2_9_1_2_1","unstructured":"Cancerincidens i Sverige2016 Nya diagnostiserade cancerfall \u00e5r 2016 Sveriges officiella statistik. 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