{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:42:14Z","timestamp":1784220134441,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant granular cell tumor GCT (mGCT) has not been well described. We sought to investigate associations between tumor characteristics, treatments and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with mGCT years 1995\u20102014 were identified using the Surveillance, Epidemiology and End Results database. Descriptive statistics regarding tumor and treatment characteristics were calculated. Chi\u2010square tests determined associations between tumor location and features. Survival analyses included Kaplan\u2010Meier functions and Cox proportional hazard ratios (HR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 113 patients included, median age was 54 years and 77.0% were female. Frequent tumor sites included soft tissues (36.3%), ovary\/testis (16.8%), and skin (11.5%). Median tumor size was 4.0\u2009cm. Metastases to regional lymph nodes (12.5%) and distant sites (11.4%) occurred. Treatments included surgery (85.0%), radiotherapy (12.4%) and chemotherapy (8.9%). Overall five and 10\u2010year cause\u2010specific survival was 74.3% and 65.2%, respectively. Survival was worse for patients with tumors &gt;5\u2009cm compared to those with tumors \u22645\u2009cm (HR\u2009=\u200934.03; 95% confidence interval [CI]: 2.57\u2010450.17), and patients with metastasis (HR\u2009=\u200915.25; 95% CI: 1.19\u2010195.72) compared with those without metastasis. Patients who underwent surgery had superior survival than those who did not (HR\u2009=\u20090.13; 95% CI: 0.05\u20100.34).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Particular tumor features and treatments are associated with superior survival. This information may be used to more accurately estimate prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25227","type":"journal-article","created":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T16:02:55Z","timestamp":1536508975000},"page":"891-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Malignant granular cell tumor: Clinical features and long\u2010term survival"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-9329","authenticated-orcid":false,"given":"Ambria S.","family":"Moten","sequence":"first","affiliation":[{"name":"Department of Surgery Temple University Hospital Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lewis Katz School of Medicine at Temple University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology Fox Chase Cancer Center Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Farma","sequence":"additional","affiliation":[{"name":"Department of Surgery Fox Chase Cancer Center Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,9]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-199907000-00002"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199807000-00001"},{"key":"e_1_2_6_1_4_1","unstructured":"Surveillance Epidemiology and End Results (SEER) program (www.seer.cancer.gov) Research Data (1973\u20132014) National Cancer Institute DCCPS Surveillance Research Program Released April 2017 Based on the 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