{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:33:51Z","timestamp":1763037231540,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Subungual melanoma (SM) is rare. The lesions are thick at the time of diagnosis. Few studies have evaluated SM in Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to investigate the factors associated with the survival of SM patients from the Brazilian National Cancer Institute.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010hundred and fifty\u2010seven patients diagnosed with SM were included in this study. We evaluated the epidemiologic, clinical, and histopathological data. Overall survival (OS) and relapse\u2010free survival (RFS) curves were computed using the Kaplan\u2010Meier method. Multivariable analyses were conducted using the Cox proportional hazard regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 157 patients, 87 (55.4%) were female. The median age was 68 years old. Median tumor depth was 6.0\u2009mm. Lesions were ulcerated in 94 (59.9%). OS and RFS rates for 5 years were 61.0% and 41.8%, respectively. Median follow\u2010up time was 28 months. The factors associated with OS were Breslow thickness and ulceration, and for RFS, they were the anatomical site, Breslow thickness, and ulceration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the largest series of SM patients. The 5\u2010year OS and RFS rates were low (61.0% and 48.2%, respectively), and the main prognostic factors for OS were Breslow thickness and ulceration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25242","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T18:18:59Z","timestamp":1538072339000},"page":"1142-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Subungual melanoma: A retrospective cohort of 157 cases from Brazilian National Cancer Institute"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2835-6597","authenticated-orcid":false,"given":"Luiz Fernando","family":"Nunes","sequence":"first","affiliation":[{"name":"Brazilian National Cancer Institute Rio de Janeiro Brazil\u2010Connective Bone Tissue Section"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9lcio L. Q.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Brazilian National Cancer Institute Rio de Janeiro Brazil\u2010Connective Bone Tissue Section"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalina J.","family":"Koifman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Quantitative Methods in Health National School of Public Health, Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02365.x"},{"issue":"1","key":"e_1_2_6_1_3_1","first-page":"96","article-title":"Subungual melanoma: an eighteen\u2010year review","volume":"116","author":"Finley RK","year":"1994","journal-title":"Surgery"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199212000-00012"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063354"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10477.x"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.4.417"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12622"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199402000-00012"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850601)55:11<2725::AID-CNCR2820551134>3.0.CO;2-V"},{"issue":"3","key":"e_1_2_6_1_11_1","first-page":"571","article-title":"Subungual melanoma","volume":"124","author":"Pack GT","year":"1967","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318073c600"},{"issue":"5","key":"e_1_2_6_1_13_1","first-page":"431","article-title":"Cutaneous melanoma in Latin America: the need for more data. 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