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Pumps were placed by laparotomy for CRLM and fluorodeoxyuridine was infused via HAIP every 28 days without systemic chemotherapy supervised by the operating surgeon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty patients were treated with HAIP, either in the adjuvant setting after liver resection or ablation of CRLM in 26 (43%) patients or with the unresectable disease in 34 (57%). Perioperative complications occurred in 19 (32%) and pump\u2010specific complications in 14 (23%) that included intrahepatic biliary stricture in one (2%). Time to liver progression was a median 9.2 months (95% CI, 3.1\u201015.3 months) in unresectable patients and liver recurrence was a median 24.7 months (2.5\u201046.9 months) in the adjuvant group. Estimated 3\u2010year overall survival from the time of HAIP placement was 64% in the adjuvant group and 37% in the unresectable group. Sarcopenia was prevalent (48%) and was associated with a worse survival (HR 2.4, 95% CI, 1.1\u20105.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A surgeon\u2010led HAIP program may achieve outcomes on par with those of experienced centers and foster strong relationships between surgical and medical oncologists.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25249","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T16:01:23Z","timestamp":1540915283000},"page":"1065-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Implementation and early outcomes for a surgeon\u2010directed hepatic arterial infusion pump program for colorectal liver metastases"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-9643","authenticated-orcid":false,"given":"Jeffery","family":"Chakedis","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery The Ohio State University Wexner Medical Center, Arthur G. 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