{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:17:26Z","timestamp":1781806646845,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T00:00:00Z","timestamp":1538870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Les Amis de Bordet","award":["NCT01834469"],"award-info":[{"award-number":["NCT01834469"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>The aim of this study was to evaluate the role of indocyanine green (ICG) fluorescence imaging (FI) for the ex vivo detection of metastatic lymph nodes (LNs) in advanced stage ovarian cancer (AOC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Paraffin\u2010embedded LNs from patients included in a previous ICG\u2010FI study (Protocol NCT01834469) were further assessed for fluorescence. Intravenous injection of ICG was delivered intraoperatively. Tumor\u2010to\u2010background ratios (TBRs) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 675 LNs from 19 patients were analyzed. The mean LN number per patient was 29.3 (median: 24; range 2\u201077). Seventy\u2010three LNs were malignant (10.8%), 602 were benign (89.2%). The mean TBR of all LNs was 1.5 (SD 0.8). With a cut\u2010off TBR of 1.3, the sensitivity, specificity, positive predictive, and negative predictive values of ICG\u2010FI for retroperitoneal LNs were 80%, 41%, 2.8%, and 99%, respectively. On univariate analysis, only the fluorescence ratio (TBR\u2009\u2265\u20091.3) was correlated with malignancy at pathology (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). No predictive factors of pathological LN status were found on multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ex vivo ICG\u2010FI of retroperitoneal LNs in AOC had good sensitivity but poor specificity. However, its high negative predictive value could make it an appropriate complementary tool to focus pathological analysis on fluorescent LNs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25263","type":"journal-article","created":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T11:44:08Z","timestamp":1538912648000},"page":"1163-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ex vivo indocyanine green fluorescence imaging for the detection of lymph node involvement in advanced\u2010stage ovarian cancer"],"prefix":"10.1002","volume":"118","author":[{"given":"Catalin\u2010Florin","family":"Pop","sequence":"first","affiliation":[{"name":"Department of Surgery, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Veys","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gomez Galdon","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Moreau","sequence":"additional","affiliation":[{"name":"Department of Data Centre and Statistics Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Larsimont","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-2520","authenticated-orcid":false,"given":"Vincent","family":"Donckier","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-1588","authenticated-orcid":false,"given":"Gabriel","family":"Liberale","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,7]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-5051-9"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.3617"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.05.014"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu175"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt333"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0122"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji102"},{"key":"e_1_2_7_1_10_1","first-page":"169","article-title":"Are nodal metastases in ovarian cancer chemoresistant lesions? 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