{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T03:09:43Z","timestamp":1785726583418,"version":"3.56.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Adamantinomas are rare bone tumors, commonly affecting the tibia. Due to the rare nature of disease, previous studies are small or from multiple centers. The purpose of this study is to investigate outcomes of patients with adamantinoma treated in a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010six histological confirmed adamantinomas of the extremities were reviewed at our institution between 1939 and 2012. Follow\u2010up data included clinical and radiographical information focusing on complications, local recurrence, metastasis, and overall survival after the treatment. The mean follow\u2010up was 16 years (range 2\u201042 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common location was the tibia (n\u2009=\u200931). Patients commonly presented with pain and swelling. The mean age was 24 years (7\u201079 years). Thirty\u2010seven patients were treated with limb salvage. The 39% of patients required a reoperation. The 10\u2010year disease specific\u2010 and recurrence free survival was 92% and 72%, with three patients having a recurrence over 15 years postoperative. Older (&gt;\u200920 years) patients and males were at increased risk of local recurrence (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment of adamantinoma of the long bone consists of limb\u2010salvage surgery. Male patients should be cautioned on their increased risk of disease recurrence, and advocate for continued surveillance of patients even greater than 15\u2010years postoperatively due to late tumor recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25269","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T21:54:03Z","timestamp":1539813243000},"page":"1150-1154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Adamantinoma of bone: Long\u2010term follow\u2010up of 46 consecutive patients"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0390-1018","authenticated-orcid":false,"given":"Matthew T.","family":"Houdek","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney E.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Jacksonville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie Y.","family":"Inwards","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris E.","family":"Wenger","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin H.","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20070301-04"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-003-0624-2"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-3-8"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201006000-00008"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199410000-00008"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0272-5"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200008000-00009"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890801)64:3<730::AID-CNCR2820640327>3.0.CO;2-P"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80077-4"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00003086-198411000-00053","article-title":"Adamantinoma of the tibia. Ultrastructural and immunohistochemic study with reference to histogenesis","volume":"190","author":"Mori H","year":"1984","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.3752.1000"},{"issue":"33","key":"e_1_2_6_1_13_1","first-page":"1522","article-title":"Adamantinoma of the proximal end of the tibia. A case","volume":"23","author":"Brain EC","year":"1994","journal-title":"Presse Med"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.923"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T03:11:47Z","timestamp":1694920307000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,17]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/jso.25269"],"URL":"https:\/\/doi.org\/10.1002\/jso.25269","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,17]]},"assertion":[{"value":"2018-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}