{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:20:06Z","timestamp":1768609206872,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>We aim to investigate whether a difference exists between right\u2010sided and left\u2010sided colon cancer at the same disease stage and subsequent liver metastasis and identify whether tumor location can independently influence survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Right\u2010sided colon cancer was defined as malignancy arising from the cecum to the transverse colon; left\u2010sided colon cancer was defined as malignancy arising from the splenic flexure to the sigmoid colon. Clinicopathological features and survival data were collected for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1442 patients were included for analysis. The median follow\u2010up time was 58.2 months. Patients with left\u2010sided colon cancer had better 5\u2010year overall survival (75.2% vs 61.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.005), 5\u2010year cancer\u2010specific survival (81.6% vs 73.4%, \n<jats:italic>P<\/jats:italic>\u2009=\u20090.001), and 5\u2010year recurrence\u2010free survival (70.9% vs 66.5%, \n<jats:italic>P<\/jats:italic>\u2009=\u20090.033) compared with patients having right\u2010sided colon cancer. After the presentation of subsequent liver metastasis, patients with primary left\u2010sided colon cancer had better 3\u2010year cancer\u2010specific survival (\n<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the multivariate analysis, cancer location was an independent prognostic factor for cancer\u2010specific survival (right vs left, HR: 1.276, 95% CI: 1.002\u20101.625).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The primary tumor location can serve as a prognostic factor for treatment outcomes either in primary stage III colon cancer or subsequent liver metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25270","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T20:07:59Z","timestamp":1541707679000},"page":"1301-1310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Primary tumor location in stage III colon cancer has prognostic impact on subsequent liver metastasis"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-4444","authenticated-orcid":false,"given":"Chun\u2010Kai","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jy\u2010Ming","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Sy","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeng\u2010Fu","family":"You","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pao\u2010Shiu","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Yuan","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Hwa","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei\u2010Ping","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinn\u2010Shiun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Yuh","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Section, Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_1_3_1","unstructured":"Ministry of Health and Welfare the Executive Yuan Republic of China. 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