{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:49:29Z","timestamp":1777888169797,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The hepatitis B virus (HBV)\u2010related intrahepatic cholangiocarcinoma (iCCA) was recognized as a unique subtype of iCCA, within particular features in demography, clinicopathology, and genealogy. However, how they predict prognosis, in particular, for HBV\u2010 and non\u2010HBV\u2013related iCCA is still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Demographic, clinicopathologic, and genetic features were retrospectively collected and reviewed to determine the specific prognostic factors, precisely predicting the overall survival (OS) in HBV\u2010related (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009119) and non\u2010HBV\u2013related (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009149) iCCA patients, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In HBV\u2010related iCCA,\n                      <jats:italic>TP53<\/jats:italic>\n                      mutation, vascular invasion, extrahepatic metastasis, and serum levels of alpha\u2010fetoprotein (AFP) were independent prognostic factors for OS. In non\u2010HBV\u2013related iCCA,\n                      <jats:italic>RAS<\/jats:italic>\n                      \/\n                      <jats:italic>RAF<\/jats:italic>\n                      mutation and lymphatic metastasis independently predicted the OS of patients. Tumor differentiation and serum levels of CA19\u20109 were significantly associated with OS in both HBV\u2010 and non\u2010HBV\u2013related iCCA patients. In a subset analysis,\n                      <jats:italic>TP53<\/jats:italic>\n                      and\n                      <jats:italic>RAS\/RAF<\/jats:italic>\n                      mutations were consistently related to poorer outcome in HBV\u2010 and non\u2010HBV\u2013related iCCA, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The HBV\u2010 and non\u2010HBV\u2013related iCCA have different prognostic factors for the OS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.25303","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T13:21:52Z","timestamp":1543324912000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Specific prognostic factors in hepatitis B virus\u2010related and non\u2010hepatitis B virus\u2013related intrahepatic cholangiocarcinoma after macroscopic curative resection"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-2969","authenticated-orcid":false,"given":"Jianbo","family":"Huang","sequence":"first","affiliation":[{"name":"Department of General Surgery Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010En","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huashan Hospital, Fudan University Shanghai 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