{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:09:51Z","timestamp":1782472191499,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Microvascular invasion (MiVI) is a histological feature of intrahepatic cholangiocarcinoma (ICC) that may be associated with biological behavior. We sought to investigate the impact of MiVI on long\u2010term survival of patients undergoing curative\u2010intent resection for ICC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1089 patients undergoing curative\u2010intent resection for ICC were identified. Data on clinicopathological characteristics, disease\u2010free survival (DFS), and overall survival (OS) were compared among patients with no vascular invasion (NoVI), MiVI, and macrovascular invasion (MaVI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 249 (22.9%) patients had MiVI, while 149 (13.7%) patients had MaVI (\u00b1MiVI). MiVI was associated with higher incidence of perineural, biliary and adjacent organ invasion, and satellite lesions (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). On multivariable analysis, MiVI was an independent risk factor of DFS (hazard ratios [HR] 1.5; 95%confidence intervals [CI], 1.3\u20101.9;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not OS (HR 1.1; 95%CI, 0.9\u20101.3;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.379). While MiVI and MaVI patients had similar DFS (median, MiVI 14.0 vs MaVI 12.0 months, HR 0.9; 95%CI, 0.7\u20101.2;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.377), OS was better among MiVI patients (median, MiVI 39.0 vs MaVI 21.0 months, HR 0.7; 95%CI, 0.5\u20100.8;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). Whereas nodal metastasis, R1 margin, and postoperative morbidity were associated with early death (\u226418 months) among patients with MiVI, only nodal metastasis was associated with late (&gt;18 months) prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Roughly 1 out of 5 patients with resected ICC had MiVI. MiVI was associated with advanced tumor characteristics and a higher risk of tumor recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.25305","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T11:31:54Z","timestamp":1542886314000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Impact of microvascular invasion on clinical outcomes after curative\u2010intent resection for intrahepatic cholangiocarcinoma"],"prefix":"10.1002","volume":"119","author":[{"given":"Liang\u2010Shuo","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-248X","authenticated-orcid":false,"given":"Matthew","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irinel","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Surgery Fundeni Clinical Institute Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo P.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Surgery Curry Cabral Hospital Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Aldrighetti","sequence":"additional","affiliation":[{"name":"Department of Surgery Ospedale San Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir K.","family":"Maithel","sequence":"additional","affiliation":[{"name":"Department of Surgery Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Pulitano","sequence":"additional","affiliation":[{"name":"Department of Surgery Royal Prince Alfred Hospital, University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd W.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Virginia Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Surgery Eastern Hepatobiliary Surgery Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Poultsides","sequence":"additional","affiliation":[{"name":"Department of Surgery Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Soubrane","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliopancreatic Surgery and Liver Transplantation AP\u2010HP, Beaujon Hospital Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Martel","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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