{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:01:17Z","timestamp":1788904877937,"version":"build-2803163510"},"reference-count":100,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>New therapeutic modalities for melanoma promise benefit in selected individuals. Efficacy appears greater in patients with lower tumor burden, suggesting an important role for risk\u2010stratified surveillance. Robust predictive markers might permit optimization of agent to patient, while low\u2010risk prognostic markers might guide more conservative management. This review evaluates protein, gene, and multiplexed marker panels that may contribute to better risk assessment and improved management of patients with cutaneous melanoma.<\/jats:p>","DOI":"10.1002\/jso.25319","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T18:24:30Z","timestamp":1544639070000},"page":"175-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Identification of risk in cutaneous melanoma patients: Prognostic and predictive markers"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-9488","authenticated-orcid":false,"given":"David M.","family":"Hyams","sequence":"first","affiliation":[{"name":"Desert Surgical Oncology, Eisenhower Medical Center Rancho Mirage California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1166-4796","authenticated-orcid":false,"given":"Robert W.","family":"Cook","sequence":"additional","affiliation":[{"name":"R&amp;D and Medical Affairs, Castle Biosciences, Inc Friendswood Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1674-4579","authenticated-orcid":false,"given":"Antonio C.","family":"Buzaid","sequence":"additional","affiliation":[{"name":"Oncology Center, Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"},{"name":"Centro Oncol\u00f3gico Antonio Erm\u00edrio de Moraes, Benefic\u00eancia Portuguesa de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_9_1_3_1","unstructured":"Noone AM Howlader N Krapcho M et al.SEER Cancer Statistics Review 1975\u20102015. Bethesda MD: National Cancer Institute; 2018."},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21409"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708539"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709030"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5286-0"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"crossref","unstructured":"JosephRW Elassaiss\u2010SchaapJ KeffordRF et al. Baseline tumor size is an independent prognostic factor for overall survival in patients with melanoma treated with pembrolizumab.Clin Cancer Res.2018; 24(20):4960\u20104967.","DOI":"10.1158\/1078-0432.CCR-17-2386"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.4059"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e328351fa4d"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"issue":"3","key":"e_1_2_9_1_12_1","first-page":"705","article-title":"The histogenesis and biologic behavior of primary human malignant melanomas of the skin","volume":"29","author":"Clark WH Jr","year":"1969","journal-title":"Cancer Res"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13171"},{"key":"e_1_2_9_1_15_1","unstructured":"CoitDG ThompsonJA AlbertiniMR et al.Melanoma Version 3.2018. NCCN Clinical Practice Guidelines in Oncology.Plymouth Meeting PA: NCCN; 2018."},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1320"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481107700816"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23093"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.01.023"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.04.031"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357907.2017.1351984"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.07.008"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004395"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15552"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2235"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000076"},{"key":"e_1_2_9_1_27_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2017-0500"},{"key":"e_1_2_9_1_28_1","doi-asserted-by":"crossref","unstructured":"WollinaU BrzezinskiP.The value of metastasectomy in stage IV cutaneous melanoma.Wien Med Wochenschr.2019;119:1-8.https:\/\/doi.org\/10.1007\/s10354-018-0630-6. [Epub ahead of print].","DOI":"10.1007\/s10354-018-0630-6"},{"key":"e_1_2_9_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)54569-9"},{"key":"e_1_2_9_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-001-0101-x"},{"issue":"10","key":"e_1_2_9_1_31_1","first-page":"1101","article-title":"Excision margins in the treatment of primary cutaneous melanoma: a systematic review of randomized controlled trials comparing narrow vs wide excision","volume":"137","author":"Lens MB","year":"2002","journal-title":"AArch Surg"},{"key":"e_1_2_9_1_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-189407000-00075"},{"key":"e_1_2_9_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-000-0087-9"},{"key":"e_1_2_9_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08260-3"},{"issue":"4","key":"e_1_2_9_1_35_1","first-page":"458","article-title":"Elective lymph node dissection in patients with melanoma: systematic review and meta\u2010analysis of randomized controlled trials","volume":"137","author":"Lens MB","year":"2002","journal-title":"AArch Surg"},{"key":"e_1_2_9_1_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197709222971202"},{"key":"e_1_2_9_1_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_9_1_38_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10140"},{"key":"e_1_2_9_1_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613210"},{"key":"e_1_2_9_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24561"},{"key":"e_1_2_9_1_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp335"},{"key":"e_1_2_9_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2007.10.004"},{"key":"e_1_2_9_1_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804710"},{"key":"e_1_2_9_1_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602043"},{"key":"e_1_2_9_1_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.306"},{"key":"e_1_2_9_1_46_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-2949-y"},{"key":"e_1_2_9_1_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1777"},{"key":"e_1_2_9_1_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1317"},{"key":"e_1_2_9_1_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000293"},{"key":"e_1_2_9_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30789-X"},{"key":"e_1_2_9_1_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-1029-z"},{"key":"e_1_2_9_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.914"},{"key":"e_1_2_9_1_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12872"},{"key":"e_1_2_9_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26724"},{"key":"e_1_2_9_1_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8020021"},{"key":"e_1_2_9_1_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-012-1322-z"},{"key":"e_1_2_9_1_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3316"},{"key":"e_1_2_9_1_58_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.7002"},{"key":"e_1_2_9_1_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.85"},{"key":"e_1_2_9_1_60_1","doi-asserted-by":"crossref","unstructured":"BrunnerG SchmitzJ BorowskiM.Impact of aGene Expression Profiling Risk Score and Web\u2010based Melanoma Outcome Calculator on the Precision of AJCC\u2010based Prognostic Assessment. Chicago IL: American Society of Clinical Oncology Annual Meeting; 2018.","DOI":"10.1200\/JCO.2018.36.15_suppl.9582"},{"key":"e_1_2_9_1_61_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.1114"},{"key":"e_1_2_9_1_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/35020115"},{"key":"e_1_2_9_1_63_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1820"},{"key":"e_1_2_9_1_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01254.x"},{"key":"e_1_2_9_1_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj103"},{"key":"e_1_2_9_1_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24899"},{"key":"e_1_2_9_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.009"},{"key":"e_1_2_9_1_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4016-3"},{"key":"e_1_2_9_1_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-018-0690-3"},{"key":"e_1_2_9_1_70_1","doi-asserted-by":"crossref","unstructured":"GreenhawBN ZitelliJA BrodlandDG.Estimation of prognosis in invasive cutaneous melanoma: an independent study of the accuracy of a gene expression profile test.Dermatol Surg.2018;44(12):1494-1500.","DOI":"10.1097\/DSS.0000000000001588"},{"key":"e_1_2_9_1_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0520-1"},{"key":"e_1_2_9_1_72_1","doi-asserted-by":"crossref","unstructured":"GastmanBR GeramiP KurleySJ CookRW LeachmanS VettoJT.Identification of patients at risk of metastasis using a prognostic 31\u2010gene expression profile in subpopulations of melanoma patients with favorable outcomes by standard criteria.J Am Acad Dermatol.2018.","DOI":"10.1016\/j.jaad.2018.07.028"},{"key":"e_1_2_9_1_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1192997"},{"key":"e_1_2_9_1_74_1","doi-asserted-by":"publisher","DOI":"10.25251\/skin.2.2.3"},{"issue":"2","key":"e_1_2_9_1_75_1","first-page":"196","article-title":"Impact of gene expre\u00a0ssion profiling on decision\u2010making in clinically node negative melanoma patients after surgical staging","volume":"17","author":"Schuitevoerder D","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_1_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802357"},{"key":"e_1_2_9_1_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412082"},{"key":"e_1_2_9_1_78_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503093"},{"key":"e_1_2_9_1_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70076-8"},{"key":"e_1_2_9_1_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-255125"},{"key":"e_1_2_9_1_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-051482"},{"key":"e_1_2_9_1_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.02.001"},{"key":"e_1_2_9_1_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2018.01.002"},{"key":"e_1_2_9_1_84_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.4327"},{"key":"e_1_2_9_1_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.044"},{"key":"e_1_2_9_1_86_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"e_1_2_9_1_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"e_1_2_9_1_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035309"},{"key":"e_1_2_9_1_89_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0575"},{"key":"e_1_2_9_1_90_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"e_1_2_9_1_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx079"},{"key":"e_1_2_9_1_92_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91190"},{"key":"e_1_2_9_1_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60958-2"},{"key":"e_1_2_9_1_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000298"},{"key":"e_1_2_9_1_95_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00073","article-title":"Landscape of microsatellite instability across 39 cancer types","volume":"2017","author":"Bonneville R","year":"2017","journal-title":"JCO Precis Oncol"},{"key":"e_1_2_9_1_96_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1490"},{"key":"e_1_2_9_1_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609376113"},{"key":"e_1_2_9_1_98_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21339"},{"key":"e_1_2_9_1_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004747"},{"key":"e_1_2_9_1_100_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0207"},{"key":"e_1_2_9_1_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0344-8"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.25319","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T07:51:41Z","timestamp":1720857101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,12]]},"references-count":100,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/jso.25319"],"URL":"https:\/\/doi.org\/10.1002\/jso.25319","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,12]]},"assertion":[{"value":"2018-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}