{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:10:22Z","timestamp":1792696222696,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Soft tissue sarcoma localization in distal extremities (DESTS) of the limbs (hand\/fingers, and foot\/toes) is unusual. The literature is scarce about their behavior and this study was designed to assess their epidemiological characteristics, outcomes, and prognosis compared to other limb localizations (OLSTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 1980 to 2010, adult DESTS and OLSTS in 22 centers were included. Demographics, tumor type, treatment modalities, and latest follow\u2010up status were collected. Primary endpoints were overall survival and local\/metastatic recurrence incidences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred five DESTS and 3001 OLSTS were included. The patients were younger, with more female and smaller tumors in DESTS. There were more clear cell\/epithelioid sarcomas, synovial sarcomas, and myxoid liposarcomas vs more dedifferentiated liposarcomas in OLSTS. DESTS tumors were less irradiated and more often amputated (24.3% vs 3.4%). The five\u2010year survival rate was 78.2% compared to 68.6% in OLSTS and after multivariate analysis, STS localization did not impact survival or local\/metastatic recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Though rare and smaller than other limb localizations, DESTS are to be considered as aggressive. Despite a higher amputation rate, the prognosis remains the same as in OLSTS. Limb sparing vs amputation should be carefully assessed in DESTS, especially if grade 3 or of a poor prognosis histological subtype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25359","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T19:09:48Z","timestamp":1546628988000},"page":"479-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Distal extremities soft tissue sarcomas: Are they so different from other limb localizations?"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-3267","authenticated-orcid":false,"given":"Jean\u2010Camille","family":"Mattei","sequence":"first","affiliation":[{"name":"Assistance Publique des H\u00f4pitaux de Marseille, H\u00f4pital Nord, D\u00e9partment de Chirurgie Orthop\u00e9dique des Prs. Curvale et Rochwerger Marseille France"},{"name":"Facult\u00e9 de M\u00e9decine de la Timone, G\u00e9n\u00e9tique M\u00e9dicale et g\u00e9nomique fonctionnelle, UMR S910 Inserm, Universit\u00e9 Aix\u2010Marseille 2 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Brouste","sequence":"additional","affiliation":[{"name":"Institut Bergonie, INSERM U 897, D\u00e9partement Biostatistique, ISPED, Universit\u00e9 Victor Segalen Bordeaux 2, Case 11 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Terrier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie et de Pathologie M\u00e9dicales Institut de Canc\u00e9rologie Gustave\u2010Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9726-9732","authenticated-orcid":false,"given":"Sylvie","family":"Bonvalot","sequence":"additional","affiliation":[{"name":"Institut Curie, D\u00e9partement de Chirurgie 8, PSL Research University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Lecesne","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Stoeckle","sequence":"additional","affiliation":[{"name":"Department of Surgery Institut Bergoni\u00e9, Regional Cancer Centre Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Italiano","sequence":"additional","affiliation":[{"name":"Departement d'oncologie Medicale CLCC Institut Bergonie Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Ranchere\u2010Vince","sequence":"additional","affiliation":[{"name":"Department of Pathology Leon Berard Center Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Meeus","sequence":"additional","affiliation":[{"name":"Department of Surgery Centre Leon Berard, University Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marick","family":"La\u00e9","sequence":"additional","affiliation":[{"name":"Service de Pathologie, Institut Curie, Paris Sciences Lettres Research University, D\u00e9partement de M\u00e9decine Diagnostique et Th\u00e9ranostique Paris France"},{"name":"Service de Pathologie, Centre Henri Becquerel, INSERM U1245, UNIROUEN, Normandie Universit\u00e9, rue d'Amiens Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Rosset","sequence":"additional","affiliation":[{"name":"D\u00e9partement Chirurgie Orthop\u00e9dique et Traumatologique 2, H\u00f4pital Trousseau, Universit\u00e9 Fran\u00e7ois\u2010Rabelais de Tours, CHU de Tours Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Rochwerger","sequence":"additional","affiliation":[{"name":"Assistance Publique des H\u00f4pitaux de Marseille, H\u00f4pital Nord, D\u00e9partment de Chirurgie Orthop\u00e9dique des Prs. 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