{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:57:14Z","timestamp":1781049434799,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003550","name":"Queensland Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Isolated limb infusion (ILI) and intralesional PV\u201010 are well described locoregional therapies for in\u2010transit melanoma. The objective of this study was to assess the effect of these treatments on survival outcomes within a cohort matched for key characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were treated using ILI or intralesional PV\u201010 at a single institution and the data prospectively recorded. Propensity score matching was performed using key covariates within a logistic regression model. The primary outcome was the melanoma\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010two patients nonrandomized were successfully matched. Both treatments produced similar best overall responses. The median melanoma\u2010specific survival (MSS) was 74.4 months from ILI and 36.4 months from PV\u201010 treatments (<jats:italic>P<\/jats:italic>\u2009=\u20090.164). Within the ILI subgroup, the 12\u2010, 24\u2010, 36\u2010 and 60\u2010month MSS rates were 85.3%, 75.3%, 60.1%, and 60.1%, respectively. From the time of PV\u201010 the corresponding 12\u2010, 24\u2010, 36\u2010, and 60\u2010month MSS rates were 82.6%, 70.0%, 53.9%, and 35.9%. On multivariate analysis, there was a significant difference in survival comparing completely with noncomplete responders (\n<jats:italic>P<\/jats:italic>\u2009=\u20090.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrate that ILI and PV\u201010 treatments for in\u2010transit disease produce comparable long\u2010term survival. Both therapies have reproducible response rates and predominantly localized and tolerable side\u2010effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25373","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T13:43:34Z","timestamp":1547559814000},"page":"717-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patients with in\u2010transit melanoma metastases have comparable survival outcomes following isolated limb infusion or intralesional PV\u201010\u2014A propensity score matched, single center study"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-3985","authenticated-orcid":false,"given":"Tavis","family":"Read","sequence":"first","affiliation":[{"name":"Queensland Melanoma Project Princess Alexandra Hospital Queensland Health Brisbane Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland, Southern Clinical School, Princess Alexandra Hospital Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Fayers","sequence":"additional","affiliation":[{"name":"Queensland Melanoma Project Princess Alexandra Hospital Queensland Health Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Thomas","sequence":"additional","affiliation":[{"name":"Queensland Melanoma Project Princess Alexandra Hospital Queensland Health Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wagels","sequence":"additional","affiliation":[{"name":"Queensland Melanoma Project Princess Alexandra Hospital Queensland Health Brisbane Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland, Southern Clinical School, Princess Alexandra Hospital Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Barbour","sequence":"additional","affiliation":[{"name":"Queensland Melanoma Project Princess Alexandra Hospital Queensland Health Brisbane Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland, Southern Clinical School, Princess Alexandra Hospital Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Mark Smithers","sequence":"additional","affiliation":[{"name":"Queensland Melanoma Project Princess Alexandra Hospital Queensland Health Brisbane Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland, Southern Clinical School, Princess Alexandra Hospital Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_10_1_2_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4100-0"},{"key":"e_1_2_10_1_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4416-4"},{"key":"e_1_2_10_1_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_10_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199804\/05)14:3<238::AID-SSU8>3.0.CO;2-9"},{"key":"e_1_2_10_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23590"},{"key":"e_1_2_10_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23553"},{"key":"e_1_2_10_1_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9954-6"},{"key":"e_1_2_10_1_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.1224"},{"key":"e_1_2_10_1_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4969-2"},{"key":"e_1_2_10_1_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0717-9"},{"key":"e_1_2_10_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e32831328c7"},{"key":"e_1_2_10_1_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9247"},{"key":"e_1_2_10_1_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4169-5"},{"key":"e_1_2_10_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24580"},{"key":"e_1_2_10_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24921"},{"issue":"9","key":"e_1_2_10_1_17_1","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1200\/JCO.1998.16.9.2906","article-title":"Prophylactic isolated limb perfusion for localized, high\u2010risk limb melanoma: results of a multicenter randomized phase III trial. 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