{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:11:07Z","timestamp":1763226667621,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased cross\u2010sectional imaging for surveillance of metastatic melanoma has led to more diagnoses of asymptomatic intussusception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a multi\u2010institutional retrospective review of patient records with a history of metastatic melanoma and a diagnosis of intussusception. Patients were divided into three groups: 1) asymptomatic patients without current evidence of melanoma (no evidence of disease [NED]); 2) asymptomatic intussusception and known active metastatic melanoma; 3) symptomatic intussusception and known active metastatic melanoma; the number of patients requiring surgery and intraoperative findings were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We reviewed 73 patients diagnosed with intussusception from 2004 to 2017. Among asymptomatic patients with NED (n\u2009=\u200916), 14 spontaneously resolved and 2 underwent pre\u2010emptive surgery without abnormal intraoperative findings. Of asymptomatic patients with active metastatic disease (n\u2009=\u200932), 25 were initially observed and 7 underwent pre\u2010emptive surgery and 9 of the 25 initially observed patients required surgery for development of symptoms. In this group, all 16 patients undergoing surgery (50% of the group) had intraoperative findings of intussusception and\/or metastatic intestinal melanoma.. All symptomatic patients with metastatic melanoma (n\u2009=\u200925) underwent surgery; all had intraoperative findings of intussusception and\/or metastatic melanoma except 1 (Meckel's diverticulum).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asymptomatic patients with NED do not require surgery and intussusception will likely resolve spontaneously. Asymptomatic patients with known metastatic melanoma may be initially observed, but a low threshold for surgery should be maintained. Symptomatic patients with known metastases should undergo surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25393","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T03:50:56Z","timestamp":1549597856000},"page":"897-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Management of intussusception in patients with melanoma"],"prefix":"10.1002","volume":"119","author":[{"given":"Matthew C.","family":"Perez","sequence":"first","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"},{"name":"Division of Surgical Oncology Emory University Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-6974","authenticated-orcid":false,"given":"James","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa 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