{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:52:54Z","timestamp":1783335174310,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic benefit of sentinel lymph node biopsy (SLNB) and factors predictive of survival specifically in patients with acral lentiginous melanoma (ALM) are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The SEER database was queried for ALM cases that underwent SLNB from 1998 to 2013. Clinicopathological factors were correlated with SLN status, overall survival (OS), and melanoma\u2010specific survival (MSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age for the 753 ALM study patients was 65 years, and 48.2% were male. Median thickness was 2\u2009mm with 38.1% of cases having ulceration. SLN metastases were detected in 194 of 753 cases (25.7%). Multivariable analysis showed that thickness, Clark level IV\u2010V, and ulceration significantly predicted for SLN metastasis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). For patients with positive SLN, 5\u2010year OS and MSS were significantly worse at 48.1% and 58.9%, respectively, compared with 78.7% and 88.5%, respectively, for patients with negative SLN (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). On multivariable analyses, older age, male gender, increasing thickness, ulceration, and a positive SLN significantly predicted for worse OS and MSS (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirms the important role of SLNB in ALM. SLN metastases are seen in 25.7% of ALM cases, providing significant prognostic information. In addition, thickness, ulceration status, and SLNB status significantly predict survival in patients with ALM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25445","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T01:21:44Z","timestamp":1552958504000},"page":"1060-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma?"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-7548","authenticated-orcid":false,"given":"Sabrina N.","family":"Pavri","sequence":"first","affiliation":[{"name":"Aesthetic and Reconstructive Surgery Institute, UF Health Cancer Center\u2010Orlando Health Orlando Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Texas A&amp;M University College Station Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajid","family":"Khan","sequence":"additional","affiliation":[{"name":"Section of Surgical Oncology, Department of Surgery, Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-2089","authenticated-orcid":false,"given":"Dale","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"issue":"5","key":"e_1_2_7_1_2_1","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1016\/j.jaad.2011.05.030","article-title":"Melanoma survival in the United States, 1992 to 2005","volume":"65","author":"Pollack LA","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.3604"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2008.609"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv294"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22539-5_14"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.0875"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.899"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1891\/9781617052958"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-018-9898-6"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v7.i2.174"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6348-2"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060992"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5502-y"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29239"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4211-7"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.115"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24660"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10140"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3089-0"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2012.05.013"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318073c600"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1826-9"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2475-3"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0101"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.1114"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362902"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200005000-00007"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800615)45:12<3012::AID-CNCR2820451223>3.0.CO;2-O"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006258"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3464-x"},{"key":"e_1_2_7_1_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709030"},{"key":"e_1_2_7_1_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708539"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.25445","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T03:12:10Z","timestamp":1694229130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,18]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jso.25445"],"URL":"https:\/\/doi.org\/10.1002\/jso.25445","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,18]]},"assertion":[{"value":"2018-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}