{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:18:31Z","timestamp":1778044711629,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cancer Center Support Grant","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}]},{"name":"Cancer Center Support Grant","award":["NCI Grant P30 CA016672"],"award-info":[{"award-number":["NCI Grant P30 CA016672"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Well\u2010differentiated liposarcomas (WDL) are often partly composed of sclerotic tissue, however, the amount varies widely between tumors, and its prognostic significance is unknown. We hypothesized that tumors with more sclerosis would behave more aggressively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Primary retroperitoneal WDL from 29 patients resected at our institution with follow\u2010up were histologically evaluated by soft tissue pathologists blinded to outcome. Tumors with\u2009\u2265\u200910% sclerosis were designated \u201csclerotic\u201d while tumors with\u2009&lt;\u200910% sclerosis were designated as \u201cminimally sclerotic\u201d. Cellular and dedifferentiated tumors were excluded. Clinical parameters and radiologic assessments on computed tomography (CT) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histological evaluation identified 13 minimally sclerotic WDL and 16 sclerotic WDL. Median follow\u2010up was 9 years (range, 3\u201020). Median recurrence\u2010free survival (RFS) and median overall survival (OS) were 6.16 and 13.9 years, respectively. Compared with patients with sclerotic WDL, those with minimally sclerotic WDL had superior RFS (HR\u2009=\u20090.17 [95% CI, 0.06\u20100.53], <jats:italic>P<\/jats:italic>\u2009=\u2009.002) and OS (log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009=\u2009.002). Sclerotic WDL exhibited higher Houndsfield Units than minimally sclerotic WDL (26 vs 1, <jats:italic>P<\/jats:italic>\u2009=\u2009.040).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Minimally sclerotic WDL were associated with more favorable outcome compared with sclerotic tumors. Assessment of sclerosis in WDL is likely a useful prognostic marker.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25585","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T16:10:57Z","timestamp":1560787857000},"page":"382-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The degree of sclerosis is associated with prognosis in well\u2010differentiated liposarcoma of the retroperitoneum"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7138-0923","authenticated-orcid":false,"given":"John S. A.","family":"Chrisinger","sequence":"first","affiliation":[{"name":"Departments of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Al\u2010Zaid","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cheu  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-8484","authenticated-orcid":false,"given":"Emily Z.","family":"Keung","sequence":"additional","affiliation":[{"name":"Surgical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk","family":"Leung","sequence":"additional","affiliation":[{"name":"Biostatistics The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Biostatistics The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-0087","authenticated-orcid":false,"given":"Christina L.","family":"Roland","sequence":"additional","affiliation":[{"name":"Surgical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keila E.","family":"Torres","sequence":"additional","affiliation":[{"name":"Surgical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Sarcoma Medical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davis R.","family":"Ingram","sequence":"additional","affiliation":[{"name":"Translational Molecular Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia","family":"Khan","sequence":"additional","affiliation":[{"name":"Translational Molecular Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeta","family":"Somaiah","sequence":"additional","affiliation":[{"name":"Sarcoma Medical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4962-3466","authenticated-orcid":false,"given":"Behrang","family":"Amini","sequence":"additional","affiliation":[{"name":"Radiology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry W.","family":"Feig","sequence":"additional","affiliation":[{"name":"Surgical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Lazar","sequence":"additional","affiliation":[{"name":"Departments of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Translational Molecular Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Genomic Medicine The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Lien","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Translational Molecular Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.08.005"},{"key":"e_1_2_9_1_3_1","first-page":"33","volume-title":"Atypical lipomatous tumour, in WHO Classification of tumours of soft tissue and bone","author":"Dei Tos AP","year":"2013"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196009\/10)13:5<932::AID-CNCR2820130512>3.0.CO;2-S"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00957030"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199705000-00003"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199708000-00002"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820301)49:5<1005::AID-CNCR2820490526>3.0.CO;2-O"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213406.95440.7a"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04348.x"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.164"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ebcc45"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896916653213"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200206000-00007"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199008000-00002"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25082"},{"key":"e_1_2_9_1_17_1","volume-title":"Statistical methods for the analysis of biomedical data","author":"Woolson RF","year":"2011"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"issue":"3","key":"e_1_2_9_1_19_1","first-page":"163","article-title":"Evaluation of survival data and two new rank order statistics arising in its consideration","volume":"50","author":"Mantel N","year":"1966","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/80.1.27"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.3747"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29931"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000366"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197902)43:2<574::AID-CNCR2820430226>3.0.CO;2-7"},{"issue":"3","key":"e_1_2_9_1_26_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/01.sla.0000086542.11899.38","article-title":"Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma.","volume":"238","author":"Singer S","year":"2003","journal-title":"Ann Surg"},{"key":"e_1_2_9_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910330108"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.25585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T16:55:45Z","timestamp":1694278545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/jso.25585"],"URL":"https:\/\/doi.org\/10.1002\/jso.25585","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2019-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}