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Patient\u2010Reported Outcomes Measurement Information System (NRS, PROMIS) were used to assess postamputation pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one patients underwent amputation with concurrent TMR during the study; 27 patients completed pain surveys; 15 had greater than 1 year follow\u2010up (mean follow\u2010up 14.7 months). Neuroma symptoms occurred significantly less frequently and with less intensity among the TMR cohort. Mean differences for PROMIS pain intensity, behavior, and interference for phantom limb pain (PLP) were 5.855 (95%CI 1.159\u201010.55; <jats:italic>P<\/jats:italic>\u2009=\u2009.015), 5.896 (95%CI 0.492\u201011.30; <jats:italic>P<\/jats:italic>\u2009=\u2009.033), and 7.435 (95%CI 1.797\u201013.07; <jats:italic>P<\/jats:italic>\u2009=\u2009.011) respectively, with lower scores for TMR cohort. For residual limb pain, PROMIS pain intensity, behavior, and interference mean differences were 5.477 (95%CI 0.528\u201010.42; <jats:italic>P<\/jats:italic>\u2009=\u2009.031), 6.195 (95%CI 0.705\u201011.69; <jats:italic>P<\/jats:italic>\u2009=\u2009.028), and 6.816 (95%CI 1.438\u201012.2; <jats:italic>P<\/jats:italic>\u2009=\u2009.014), respectively. Fifty\u2010six percent took opioids before amputation compared to 22% at 1 year postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multidisciplinary care of amputees including concurrent amputation and TMR, multimodal postoperative pain management, amputee\u2010centered rehabilitation, and peer support demonstrates reduced incidence and severity of neuroma and PLP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25586","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T04:00:28Z","timestamp":1560484828000},"page":"348-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Targeted muscle reinnervation in oncologic amputees: Early experience of a novel institutional protocol"],"prefix":"10.1002","volume":"120","author":[{"given":"John H.","family":"Alexander","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The Ohio State University James Wexner Medical Center  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanas W.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"West","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Ohio State University Wexner Medical Center  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Compston","sequence":"additional","affiliation":[{"name":"Department of Oncologic Rehabilitation The Ohio State University James Comprehensive Cancer Center  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Fugitt","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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