{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:34:18Z","timestamp":1772951658599,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2017GXNSFBA198098"],"award-info":[{"award-number":["2017GXNSFBA198098"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of secondary ABCs and other relevant clinical factors on the postoperative recurrence of GCTBs of the extremities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 256 cases of GCTBs of the extremities that were treated surgically at our institution. Among them, there were 60 patients diagnosed with GCTBs combined with secondary ABCs and 196 patients diagnosed with simple GCTBs. Intralesional curettage and tumor resection were performed in 136 and 120 cases, respectively. Univariate analysis, Kaplan\u2010Meier survival analysis, and multivariate regression analysis were used to assess the factors for postoperative recurrence. The follow\u2010up period was at least 24 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total postoperative recurrence rate was 32%. The recurrence rate in the secondary ABCs group was significantly higher than that in the simple GCTBs group (53.3% vs 25.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Curettage was associated with a higher recurrence rate than tumor resection (42.5% vs 20%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Kaplan\u2010Meier survival analysis showed that patients with GCTBs combined with secondary ABCs and who were treated by intralesional curettage had a decreased disease\u2010free survival rate. The hazard ratio was 2.18 (95% confidence interval [CI], 1.15\u20104.13) for the group of GCTB combined with ABCs (\n<jats:italic>P<\/jats:italic>\u2009=\u20090.01) and 1.97 (95% CI, 1.22\u20107.50) for the curettage group (\n<jats:italic>P<\/jats:italic>\u2009=\u20090.01), respectively. Multivariate regression analysis revealed that the presence of secondary ABCs and curettage were independent factors for recurrence of GCTBs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the results of this study, the presence of secondary ABCs is a potential risk factor for postoperative relapse of GCTBs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25588","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T14:24:25Z","timestamp":1561040665000},"page":"359-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Giant cell tumors combined with secondary aneurysmal bone cysts are more likely to develop postoperative recurrence: A retrospective study of 256 cases"],"prefix":"10.1002","volume":"120","author":[{"given":"HaiJun","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu","family":"Moro","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenYu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YinJuan","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Public Health Guangxi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZengMing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4087-3183","authenticated-orcid":false,"given":"Yun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"e_1_2_12_1_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.O.00156"},{"key":"e_1_2_12_1_3_1","first-page":"679","article-title":"Aggressive giant cell tumour of bone","volume":"47","author":"Faisham WI","year":"2006","journal-title":"Singapore Med J"},{"key":"e_1_2_12_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36332"},{"key":"e_1_2_12_1_5_1","first-page":"1230","article-title":"Factors of local recurrence of giant cell tumor of long bone after treatment: plain radiographs, pathology and surgical procedures","volume":"94","author":"Chanchairujira K","year":"2011","journal-title":"J Med Assoc Thailand"},{"key":"e_1_2_12_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000128280.59965.e3"},{"key":"e_1_2_12_1_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710014815"},{"key":"e_1_2_12_1_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.01922"},{"key":"e_1_2_12_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.05.023"},{"key":"e_1_2_12_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0427-x"},{"key":"e_1_2_12_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2009.09.002"},{"key":"e_1_2_12_1_12_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199412000-00009"},{"key":"e_1_2_12_1_13_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-20-04-233"},{"key":"e_1_2_12_1_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.164.3.7863874"},{"key":"e_1_2_12_1_15_1","first-page":"2921","article-title":"Aneurysmal bone cyst. 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