{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:34:57Z","timestamp":1765280097343,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005940","name":"Dansk Kr\u00e6ftforsknings Fond","doi-asserted-by":"publisher","award":["161.000 Danish krone"],"award-info":[{"award-number":["161.000 Danish krone"]}],"id":[{"id":"10.13039\/501100005940","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and objectives:<\/jats:bold> Hypertherm intraperitoneal chemotherapy (HIPEC) is increasingly used in the treatment of ovarian, tubal, and primary peritoneal cancer (OC). The aim was to evaluate short\u2010term morbidity of cytoreductive surgery (CRS) and carboplatin HIPEC.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Prospective feasibility study performed from January 2016 to December 2017. Twenty\u2010five patients with primary OC (FIGO III\u2010IV) received upfront or interval CRS combined with carboplatin HIPEC at dose 800\u2009mg\/m\n<jats:sup>2<\/jats:sup>. Primary outcome measurements: grade 3 to 5 adverse events within 30 days according to Common Terminology Criteria for Adverse Events. Secondary outcome measurements: reoperation rate, length of hospital stay, readmission rate, and time from surgery to systemic chemotherapy administration.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> No deaths (grade 5) or grade 4 adverse events were observed. Eleven patients (44.0%) experienced at least one grade 3 adverse event, the most common being an infection (28.0%) and neutropenia (12.0%). The reoperation rate was 8.0%. The median hospital stay was 14 days (range 9\u201025 days), and five patients (25.0%) were readmitted within 30 days after surgery. Median time from surgery to the administration of the first dose of systemic chemotherapy was 41 days (range 24\u201081 days).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our small\u2010scale prospective study supports that CRS and carboplatin HIPEC used for primary advanced\u2010stage OC is feasible with acceptable morbidity.<\/jats:p>","DOI":"10.1002\/jso.25603","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T04:59:35Z","timestamp":1562129975000},"page":"550-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Morbidity after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with carboplatin used for ovarian, tubal, and primary peritoneal cancer"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-7037","authenticated-orcid":false,"given":"Mette Schou","family":"Mikkelsen","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thora","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone Kjeld","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Blaakaer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene Hjerrild","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"e_1_2_8_1_2_1","unstructured":"GLOBOCAN database2012. 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