{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:50:58Z","timestamp":1787061058388,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Management practices for acute appendicitis are changing. In cases of nonoperative treatment, the risk of missed or delayed diagnosis of malignancy should be considered. We aimed to identify predictors associated with appendiceal cancer diagnosis after appendectomy for acute appendicitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study was performed using the National Surgical Quality Improvement Program (NSQIP) appendectomy\u2010targeted data set from 2016 to 2017. A total of 21\u2009069 patients with imaging\u2010confirmed or imaging indeterminate appendicitis who underwent appendectomy were included. Logistic regression was used to identify predictors of cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Increasing age had an increasing monotonic relationship with the odds of pathologic cancer diagnosis after appendectomy (age 50\u201059 odds ratio [OR], 2.08, 95% confidence interval [CI], 1.28\u20103.39,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.003; age 60\u201069 OR, 2.89, 95% CI, 1.72\u20104.83,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001; age 70\u201079 OR, 3.85, 95% CI, 2.08\u20107.12,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001; age &gt;80 OR, 5.32, 95% CI, 2.38\u201011.9,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Other significant predictors included obesity, morbid obesity, normal preoperative white blood cell count, and imaging indeterminate for appendicitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When counseling patients regarding operative vs nonoperative treatment options for management of acute appendicitis, the rising risk of a delayed or missed cancer diagnosis with increasing age must be discussed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.25608","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T01:14:20Z","timestamp":1562202860000},"page":"452-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Risk of appendiceal cancer in patients undergoing appendectomy for appendicitis in the era of increasing nonoperative management"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-3753","authenticated-orcid":false,"given":"Pamela","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"},{"name":"Center for Surgery and Public Health, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-608X","authenticated-orcid":false,"given":"Justin C.","family":"McCarty","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"},{"name":"Division of Plastic Surgery, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9029-7044","authenticated-orcid":false,"given":"Adam C.","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart R.","family":"Lipsitz","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel E.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Irani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Bleday","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelya","family":"Melnitchouk","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"},{"name":"Center for Surgery and Public Health, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00275-5"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002039"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0304-6"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6154"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6482"},{"issue":"5","key":"e_1_2_9_1_7_1","first-page":"459","article-title":"Comparison of operative and non operative management of acute appendicitis","volume":"15","author":"Turhan AN","year":"2009","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60410-8"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820207"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9337-2"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.05.025"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-014-2726-7"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.4373"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.0486"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2015.11.009"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.09.005"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3003"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e2156"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10589"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-014-1934-7"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236899"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.09.009"},{"issue":"4","key":"e_1_2_9_1_24_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1177\/000313481508100432","article-title":"Use and accuracy of computed tomography scan in diagnosing perforated appendicitis","volume":"81","author":"Verma R","year":"2015","journal-title":"Am Surg"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9350"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-017-0122-9"},{"key":"e_1_2_9_1_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481207800344"},{"key":"e_1_2_9_1_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.1212"},{"key":"e_1_2_9_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2014.09.020"},{"key":"e_1_2_9_1_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38926.629329.AE"},{"key":"e_1_2_9_1_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1411250"},{"key":"e_1_2_9_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.02.010"},{"key":"e_1_2_9_1_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.4282"},{"key":"e_1_2_9_1_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.5310"},{"key":"e_1_2_9_1_35_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-0048"},{"key":"e_1_2_9_1_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001670"},{"key":"e_1_2_9_1_37_1","unstructured":"American College of Surgeons National Surgical Quality Improvement Program. Participant Use Data File 2017.https:\/\/www.facs.org\/quality\u2010programs\/acs\u2010nsqip\/participant\u2010use. Accessed June 13 2019."}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.25608","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T12:56:25Z","timestamp":1694264185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/jso.25608"],"URL":"https:\/\/doi.org\/10.1002\/jso.25608","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,3]]},"assertion":[{"value":"2019-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}