{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:59:40Z","timestamp":1760061580859,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>This current study assessed the value of S\u2010100B measurement to guide fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT) scanning for detecting recurrent disease in stage III melanoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 100 stage III melanoma patients in follow\u2010up after curative lymph node dissection. Follow\u2010up visits included physical examination and S\u2010100B monitoring. FDG PET\/CT scanning was indicated by clinical symptoms and\/or elevated S\u2010100B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 100 patients, 13 (13%) had elevated S\u2010100B without clinical symptoms, of whom 7 (54%) showed disease evidence upon FDG PET\/CT scanning. Twenty\u2010six patients (26%) had clinical symptoms with normal S\u2010100B and FDG PET\/CT revealed metastasis in 20 (77%). Three patients had clinical symptoms and elevated S\u2010100B, and FDG PET\/CT revealed metastasis in all three (100%). Overall, FDG PET\/CT scanning revealed metastasis in 30 of the 42 patients (71.4%). For seven recurrences, elevated S\u2010100B prompted early detection of asymptomatic disease; 10% of all asymptomatic patients in follow\u2010up, 23% of all patients with recurrent disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>S\u2010100B cannot exclude recurrent disease during follow\u2010up of stage III melanoma. However, adding S\u2010100B measurement to standard clinical assessment can guide FDG PET\/CT scanning for detecting recurrent melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25682","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T04:50:10Z","timestamp":1567140610000},"page":"1031-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["S\u2010100B as an extra selection tool for FDG PET\/CT scanning in follow\u2010up of AJCC stage III melanoma patients"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-207X","authenticated-orcid":false,"given":"Eric A.","family":"Deckers","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin P.","family":"Wevers","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke C.","family":"Muller Kobold","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Damude","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otis M.","family":"Vrielink","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"van Ginkel","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas B.","family":"Been","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara L.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald J.","family":"Hoekstra","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schelto","family":"Kruijff","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr128"},{"key":"e_1_2_9_1_3_1","unstructured":"Melanoom incidentie. 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