{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:51:57Z","timestamp":1760784717770,"version":"3.37.3"},"reference-count":77,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether patients with advanced tubo\u2010ovarian high\u2010grade serous cancer (HGSC) fare better after upfront debulking surgery (UDS) or neoadjuvant chemotherapy with interval debulking surgery (NACT\u2010IDS) remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied patients with HGSC who underwent UDS or NACT\u2010IDS between July 2000 and December 2015, with peritonectomy procedures combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Clinical reports were included peritoneal cancer index (PCI), NACT responses, surgical complexity score (SCS), completeness of cytoreduction (CC), complete follow\u2010up with timing, site, and treatment of recurrence. Outcome measures were morbidity, progression\u2010free survival (PFS), PFS2, and overall survival during a mean 5\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 34 patients (23.6%) underwent UDS and 110 (76.4%) NACT\u2010IDS both combined with HIPEC. At a median 66.3\u2010month follow\u2010up, patients who underwent UDS or NACT\u2010IDS had similar outcomes. NACT subgroup responses correlated with PCI, SCS, morbidity, and CC. Patients who underwent UDS had lower recurrence rates than those who responded partly or poorly to NACT (PFS, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.04; PFS2, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Despite HIPEC, the peritoneal disease recurred in 42.5% of the overall patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with primary HGSC who undergo UDS or NACT\u2010IDS, despite similar outcomes, peritonectomy procedures combined with HIPEC seem unable to prevent peritoneal recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25703","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T04:23:32Z","timestamp":1568780612000},"page":"1208-1219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Upfront debulking surgery versus interval debulking surgery for advanced tubo\u2010ovarian high\u2010grade serous carcinoma and diffuse peritoneal metastases treated with peritonectomy procedures plus HIPEC"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-2315","authenticated-orcid":false,"given":"Daniele","family":"Biacchi","sequence":"first","affiliation":[{"name":"Cytoreductive Surgery and HIPEC Unit, Department of Surgery \u201cPietro Valdoni\u201d Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Accarpio","sequence":"additional","affiliation":[{"name":"Cytoreductive Surgery and HIPEC Unit, Department of Surgery \u201cPietro Valdoni\u201d Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Ansaloni","sequence":"additional","affiliation":[{"name":"Department of Surgery General and Emergency Surgery Unit Bufalini Hospital Cesena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Macr\u00ec","sequence":"additional","affiliation":[{"name":"Department of Surgery, Peritoneal Surface Malignancy and Soft Tissue Sarcoma Program University of Messina  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-6236","authenticated-orcid":false,"given":"Antonio","family":"Ciardi","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological, and Pathological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orietta","family":"Federici","sequence":"additional","affiliation":[{"name":"Department of Surgery Surgical Oncology National Cancer Institute Regina Elena Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Spagnoli","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infection Disease, Statistics Section Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Cavaliere","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Advanced Oncologic Therapies Unit AUSL della Romagna Forl\u00ec Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Vaira","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Candiolo Institute for Cancer Research and Treatment  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-7930","authenticated-orcid":false,"given":"Paolo","family":"Sapienza","sequence":"additional","affiliation":[{"name":"Department of Surgery \u201cPietro Valdoni\u201d Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5513-6349","authenticated-orcid":false,"given":"Paolo","family":"Sammartino","sequence":"additional","affiliation":[{"name":"Cytoreductive Surgery and HIPEC Unit, Department of Surgery \u201cPietro Valdoni\u201d Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.224"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908806"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62223-6"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.0723"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.01.008"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000767"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.6907"},{"key":"e_1_2_6_1_9_1","unstructured":"National Comprehensive Cancer Network Guidelines: Epithelial Ovarian Cancer (including Fallopian Tube Cancer and Primary Peritoneal Cancer).https:\/\/www.nccn.org\/professionals\/physician_gls\/default.aspx#site"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.5.1248"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24149"},{"key":"e_1_2_6_1_12_1","first-page":"CD007565","article-title":"Optimal primary surgical treatment for advanced epithelial ovarian cancer","volume":"8","author":"Elattar A","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.05.040"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.5516"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.5500"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.09.002"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.07.004"},{"issue":"15","key":"e_1_2_6_1_18_1","first-page":"15","article-title":"TRUST: trial of radical upfront surgical therapy in advanced ovarian cancer (ENGOT ov33 \/ AGO\u2010OVAR OP7","volume":"35","author":"Mahner S","year":"2017","journal-title":"J Clin Oncol"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.1239"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.11.035"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000946"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.07.004"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001244"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708618"},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy198"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.09.007"},{"issue":"2","key":"e_1_2_6_1_27_1","article-title":"Cytoreductive surgery using peritonectomy and visceral resections for peritoneal surface malignancy","volume":"2","author":"Sugarbaker PH","year":"2013","journal-title":"Transl Gastrointest Cancer"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-019-00875-z"},{"key":"e_1_2_6_1_29_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5686-1"},{"key":"e_1_2_6_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_6_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1247-5_23"},{"volume-title":"AJCC Cancer Staging Manual","year":"2017","author":"American Joint Committee on Cancer","key":"e_1_2_6_1_32_1"},{"key":"e_1_2_6_1_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_6_1_34_1","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. Published: May 28 2009 (v4.03: June 14 2010)."},{"key":"e_1_2_6_1_35_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2015.26.2.155"},{"key":"e_1_2_6_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.05.032"},{"key":"e_1_2_6_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.09.002"},{"key":"e_1_2_6_1_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.5212"},{"key":"e_1_2_6_1_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2657"},{"key":"e_1_2_6_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.05.026"},{"key":"e_1_2_6_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32552-2"},{"key":"e_1_2_6_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.11.011"},{"key":"e_1_2_6_1_43_1","doi-asserted-by":"publisher","DOI":"10.14694\/EDBK_160624"},{"key":"e_1_2_6_1_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000967"},{"key":"e_1_2_6_1_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr467"},{"key":"e_1_2_6_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.04.007"},{"key":"e_1_2_6_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.04.679"},{"issue":"1","key":"e_1_2_6_1_48_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ygyno.2012.01.001","article-title":"Re: \u201ccytoreductive surgery and hyperthermic intraperitoneal chemotherapy as upfront therapy for advanced epithelial ovarian cancer: multi\u2010institutional phase II trial.\u201d\u2014proposal of a clinical trial of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in advanced ovarian cancer, the CHORINE study","volume":"125","author":"Ansaloni L","year":"2012","journal-title":"Gynecol Oncol"},{"key":"e_1_2_6_1_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-012-0278-0"},{"key":"e_1_2_6_1_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31826a3559"},{"key":"e_1_2_6_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.08.014"},{"key":"e_1_2_6_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.11.021"},{"key":"e_1_2_6_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.12.017"},{"key":"e_1_2_6_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.11.010"},{"key":"e_1_2_6_1_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24406"},{"key":"e_1_2_6_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.04.011"},{"key":"e_1_2_6_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2016.07.001"},{"key":"e_1_2_6_1_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001173"},{"key":"e_1_2_6_1_59_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4329-7"},{"key":"e_1_2_6_1_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-019-00914-9"},{"key":"e_1_2_6_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2019.03.007"},{"key":"e_1_2_6_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10527"},{"key":"e_1_2_6_1_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313823"},{"key":"e_1_2_6_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.01.014"},{"key":"e_1_2_6_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.11.007"},{"key":"e_1_2_6_1_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000241"},{"key":"e_1_2_6_1_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000007"},{"key":"e_1_2_6_1_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2017.01.001"},{"key":"e_1_2_6_1_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31829f17c9"},{"key":"e_1_2_6_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.09.011"},{"key":"e_1_2_6_1_71_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3599-4"},{"key":"e_1_2_6_1_72_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2018.29.e53"},{"key":"e_1_2_6_1_73_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6033-x"},{"key":"e_1_2_6_1_74_1","doi-asserted-by":"publisher","DOI":"10.4081\/joper.2017.59"},{"key":"e_1_2_6_1_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.11.007"},{"key":"e_1_2_6_1_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3573-1"},{"key":"e_1_2_6_1_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.06.002"},{"key":"e_1_2_6_1_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.07.006"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.25703","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:09:55Z","timestamp":1693220995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,17]]},"references-count":77,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/jso.25703"],"URL":"https:\/\/doi.org\/10.1002\/jso.25703","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"type":"print","value":"0022-4790"},{"type":"electronic","value":"1096-9098"}],"subject":[],"published":{"date-parts":[[2019,9,17]]},"assertion":[{"value":"2019-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}