{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:13:59Z","timestamp":1760382839738,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CORPG3G0101"],"award-info":[{"award-number":["CORPG3G0101"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vascularized lymph node transfer (VLNT) is an effective surgery for extremity lymphedema. This study evaluated a lymphatic drainage device (LDD) for the drainage of accumulated fluid into the venous system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Micropore filtering membranes with pore sizes of 5, 0.65, and 0.22\u2009\u03bcm polyvinylidene difluoride, and 0.8\u2009\u03bcm Nylon Net Filter were evaluated to determine the in vitro efficiency of drainage flow of an LDD. The two superior membranes were further used for the evaluation of the inflow and outflow of the LDD in vivo using 5% albumin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 5\u2009minutes, the volumes drained with 5, 0.65, and 0.22\u2009\u03bcm polyvinylidene difluoride and 0.8\u2009\u03bcm nylon membranes were 15.2, 2.77, 2.37, and 0.59\u2009mL, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). At 10\u2009minutes, the collected volumes of 5 and 0.65\u2009\u03bcm polyvinylidene difluoride were 1788 and 1051\u2009\u03bcL (<jats:italic>P\u2009=\u2009<\/jats:italic>.3). The indocyanine green fluorescence was detected at 50\u2009seconds for the 5\u2009\u03bcm polyvinylidene difluoride membrane but not for the 0.65\u2009\u03bcm membrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study successfully demonstrated the proof\u2010of\u2010concept of the LDD prototype that mimicked VLNT with drainage of 5% albumin into the venous system in a rat model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25707","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T04:19:47Z","timestamp":1569471587000},"page":"1162-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy validation of a lymphatic drainage device for lymphedema drainage in a rat model"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-2959","authenticated-orcid":false,"given":"Ming\u2010Huei","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Collage of Medical Chang Gung University  Taoyuan Taiwan"},{"name":"Center for Tissue Engineering Chang Gung Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Collage of Medical Chang Gung University  Taoyuan Taiwan"},{"name":"Center for Tissue Engineering Chang Gung Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Tee","sequence":"additional","affiliation":[{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Collage of Medical Chang Gung University  Taoyuan Taiwan"},{"name":"Center for Tissue Engineering Chang Gung Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ting","family":"Hong","sequence":"additional","affiliation":[{"name":"Institute of Mechatronic Engineering, National Taipei University of Technology  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Mechatronic Engineering, National Taipei University of Technology  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"e_1_2_9_1_2_1","first-page":"4005","article-title":"Lower body lymphedema in patients with gynecologic cancer","volume":"37","author":"Biglia N","year":"2017","journal-title":"Anticancer Res"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i3.241"},{"key":"e_1_2_9_1_4_1","first-page":"118","article-title":"Post\u2010breast cancer lymphedema: incidence increases from 12 to 30 to 60 months","volume":"43","author":"Armer JM","year":"2010","journal-title":"Lymphology"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.02.016"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21035"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12B <2861::AID-CNCR39>3.0.CO;2-V"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844318609006311"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-947150"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197708000-00006"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.04.017"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31819e6529"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31828bd3b3"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.01.007"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.10.011"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000437257.78327.5b"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25518"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004673"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820291209"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.0043"},{"key":"e_1_2_9_1_21_1","unstructured":"ChengMH YangCY.LDD PDVF in vivo test; 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