{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:03:22Z","timestamp":1783119802804,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Hyperthermic intrathoracic chemotherapy (HITOC) is used for the treatment of malignant pleural tumors. Although HITOC proved to be safe, postoperative renal failure due to nephrotoxicity of intrapleural cisplatin remains a concern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center study was performed retrospectively in patients who underwent pleural tumor resection and HITOC between September 2008 and December 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 84 patients (female <jats:italic>n<\/jats:italic>\u2009=\u200933; 39.3%) with malignant pleural tumors underwent surgical cytoreduction with subsequent HITOC (60\u2009minutes; 42\u00b0C). During the study period, we gradually increased the dosage of cisplatin (100\u2013150\u2009mg\/m<jats:sup>2<\/jats:sup> BSA n\u2009=\u200936; 175\u2009mg\/m<jats:sup>2<\/jats:sup> BSA n\u2009=\u20092) and finally added doxorubicin (cisplatin 175\u2009mg\/m<jats:sup>2<\/jats:sup> BSA\/doxorubicin 65\u2009mg; n\u2009=\u200946). All patients had perioperative fluid balancing. The last 54 (64.3%) patients also received perioperative cytoprotection. Overall 29 patients (34.5%) experienced renal insufficiency. Despite higher cisplatin concentrations, patients with cytoprotection showed significantly lower postoperative serum creatinine levels after 1 week (<jats:italic>P<\/jats:italic>\u2009=\u2009.006) and at discharge (<jats:italic>P<\/jats:italic>\u2009=\u2009.020). Also, they showed less intermediate and severe renal insufficiencies (5.6% vs 13.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adequate perioperative fluid management and cytoprotection seem to be effective in protecting renal function. This allows the administration of higher intracavitary cisplatin doses without raising the rate of renal insufficiencies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25726","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T04:00:16Z","timestamp":1570766416000},"page":"1220-1226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Adequate nephroprotection reduces renal complications after hyperthermic intrathoracic chemotherapy"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5364-6206","authenticated-orcid":false,"given":"Till","family":"Markowiak","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery University Medical Center Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Kerner","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery 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