{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:52:16Z","timestamp":1762005136652,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,24]],"date-time":"2019-11-24T00:00:00Z","timestamp":1574553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammation status plays an important role in the natural history of malignancy. Consequently, hematological markers of systemic inflammation may predict prognosis in neoplasms. This study evaluated the value of cellular blood components changes during neoadjuvant chemoradiotherapy followed by esophagectomy for cancer in predicting prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 149 patients was analyzed. Cellular components of blood were assessed before neoadjuvant therapy (A); before surgery (B); and 3 to 5 months after surgery (C); for the following outcomes: pathological response, overall survival (OS), and disease\u2010free survival (DFS). Univariate and multivariate Cox regression models were applied to evaluate the independent prognostic significance of blood count variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low hematocrit (Ht) (C) (HR, 0.85; 95% CI, 0.79\u20100.92) and high neutrophil\u2010to\u2010lymphocyte ratio (NLR) (C) (HR, 1.07; 95% CI, 1.07\u20101.10) were related to poor OS. Low Hb (C) (HR, 0.72; 95% CI, 0.58\u20100.88), red cell distribution width (RDW) (C\u2010A) (HR, 1.16; 95% CI, 1.02\u20101.31), and NLR (C\u2010A) (1.06; 95% CI, 1.03\u20101.09) were related to poor DFS. RDW (B\u2010A) (HR, 1.15; 95% CI, 1.08\u20101.22), RDW (C) (HR, 1.12; 95% CI, 1.04\u20101.2), NLR (C) (HR, 1.12; 95% CI, 1.08\u20101.17) were related to systemic recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Variables of routine blood count are easily assessable and their changes throughout trimodal therapy for esophageal carcinoma provide important information for cancer patient's prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25778","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T05:29:46Z","timestamp":1574659786000},"page":"784-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The value of cellular components of blood in the setting of trimodal therapy for esophageal 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