{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:58:40Z","timestamp":1784329120629,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary aldosteronism (PA) is the most common cause of secondary hypertension; early diagnosis and intervention correlate with outcomes. We hypothesized that race may influence clinical presentation and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of patients with PA (1997\u20102017) who underwent adrenal vein sampling (AVS). Patients were classified by self\u2010reported race as black or non\u2010black. Improvement was defined as postoperative decrease in mean arterial pressure (MAP), antihypertensive medications (AHM), or both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among patients undergoing AVS (n\u2009=\u2009443), 287 underwent adrenalectomy. Black patients (28.2%) had higher body mass index (33.9 vs 31.8\u2009kg\/m<jats:sup>2<\/jats:sup>;<jats:italic>P<\/jats:italic>\u2009=\u2009.01), longer median duration of hypertension (12 vs 10 years;<jats:italic>P<\/jats:italic>\u2009=\u2009.003), higher modified Elixhauser comorbidity index (2 vs 1;<jats:italic>P<\/jats:italic>\u2009=\u2009.004), and lower median income ($47\u2009134 vs $78\u2009280;<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Black patients had similar aldosterone:renin ratios (150 vs 135.6 [ng\/dL]\/[ng\u00b7mL\u00b7<jats:sup>\u22121<\/jats:sup>hr<jats:sup>\u22121<\/jats:sup>];<jats:italic>P<\/jats:italic>\u2009=\u2009.23) compared to non\u2010blacks. At long\u2010term follow\u2010up, black patients had a similar requirement for AHM (1 vs 0;<jats:italic>P<\/jats:italic>\u2009=\u2009.13) but higher MAP (100.6 vs 95.3 mm\u2009Hg;<jats:italic>P<\/jats:italic>\u2009=\u2009.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Black patients present with longer duration of hypertension and more comorbidities. They are equally likely to lateralize on AVS, suggesting similar disease phenotype. However, black patients demonstrate less improvement with adrenalectomy; this may reflect a delay in diagnosis or concomitant essential hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25806","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T04:39:45Z","timestamp":1576816785000},"page":"456-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical presentation and surgical outcomes in primary aldosteronism differ by race"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-0221","authenticated-orcid":false,"given":"Victoria M.","family":"Gershuni","sequence":"first","affiliation":[{"name":"Division of Endocrine and Oncologic Surgery, Department of Surgery Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae 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