{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T20:49:27Z","timestamp":1788122967786,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Somatostatin analog functional imaging with gallium\u201068 (Ga\u201068) dotatate positron emission tomography\/computed tomography (PET\/CT) has demonstrated superiority in lesion detection in patients with neuroendocrine tumors (NETs). The clinical impact of this imaging modality on US surgical and medical oncology practices has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with NET at our institution who received an initial Ga\u201068 dotatate PET\/CT between July 2017 and September 2018 were included. Ga\u201068 dotatate PET\/CT was compared with prior imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 101 eligible patients, 51 of 50 were female\/male, site of origin was gastroenteropancreatic (75%), unknown primary (13%), lung (8%), thymus (2%), and other (2%). All NETs were histologically well\/moderately differentiated. Ga\u201068 dotatate imaging findings altered management in 36 (35.6%) patients: documentation of progression led to the initiation of systemic therapy in 14 patients, obviated the need for biopsy in four patients, and altered surgical plans in 7 of 14 (50%) patients referred for surgery. In 11 patients, decisions regarding peptide receptor radionucleotide therapy and somatostatin analogs were altered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this series, Ga\u201068 dotatate PET\/CT altered diagnosis and management in one\u2010third of patients and changed operative plans in half of the patients who were referred for surgical evaluation. These results support the routine use of this imaging in the care of patients with early\u2010stage and advanced NETs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25812","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T04:55:05Z","timestamp":1576731305000},"page":"480-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Impact of initial imaging with gallium\u201068 dotatate PET\/CT on diagnosis and management of patients with neuroendocrine tumors"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-3788","authenticated-orcid":false,"given":"Angelena","family":"Crown","sequence":"first","affiliation":[{"name":"Department of General, Thoracic and Vascular Surgery Virginia Mason Medical Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio G.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of General, Thoracic and Vascular Surgery Virginia Mason Medical Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethi","family":"Raghu","sequence":"additional","affiliation":[{"name":"Department of Radiology Virginia Mason Medical Center Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Virginia Mason Medical Center Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Virginia Mason Medical Center Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Alseidi","sequence":"additional","affiliation":[{"name":"Department of General, Thoracic and Vascular Surgery Virginia Mason Medical Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misho","family":"Hubka","sequence":"additional","affiliation":[{"name":"Department of General, Thoracic and Vascular Surgery Virginia Mason Medical Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rosales","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Virginia Mason Medical Center Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Virginia Mason Medical Center Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagen","family":"Kennecke","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Virginia Mason Medical Center Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23883"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443167"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.06.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(03)00230-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.05.030"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.053314"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085237"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-002-0609-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.0987"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0450-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.035667"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.165803"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-010-0374-1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.185587"},{"key":"e_1_2_8_19_1","unstructured":"National Comprehensive Cancer Network. (2019). Neuroendocrine and adrenal tumors (version 1.2019). Retrieved fromhttps:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/neuroendocrine.pdf. Accessed October 24 2019."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.202275"},{"key":"e_1_2_8_21_1","volume-title":"WHO classification of tumours of endocrine organs","author":"Lloyd RV","year":"2017"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000850"},{"issue":"2","key":"e_1_2_8_23_1","first-page":"S219","article-title":"Scintigraphy and radionuclide therapy with [indium\u2010111\u2010labelled\u2010diethyl triamine penta\u2010acetic acid\u2010D\u2010Phe1]\u2010octreotide","volume":"31","author":"Krenning EP","year":"1999","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.114165"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1935-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2011.02327.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.8510"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316158"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.2553"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009290"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31815e4557"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26124"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3981-2"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.25812","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:59:51Z","timestamp":1694095191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/jso.25812"],"URL":"https:\/\/doi.org\/10.1002\/jso.25812","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]},"assertion":[{"value":"2019-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}