{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:04:03Z","timestamp":1777647843676,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772522"],"award-info":[{"award-number":["81772522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M643325"],"award-info":[{"award-number":["2018M643325"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M643327"],"award-info":[{"award-number":["2018M643327"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The accuracy of the current staging system for predicting the overall survival (OS) of patients with ampullary carcinoma (AC) is still unsatisfactory, especially in node\u2010negative (N0) patients. We aimed at establishing a nomogram to accurately predict OS in N0 AC.<\/jats:p><\/jats:sec><jats:sec><jats:title>MethodS<\/jats:title><jats:p>This study enrolled 697 N0 AC patients from the Surveillance, Epidemiology, and End Results database (design cohort [DC], n\u2009=\u2009697) and the First Affiliated Hospital of Sun Yat\u2010sen University (validation cohort [VC], n\u2009=\u2009112), who underwent surgical resection. The nomogram was established by using prognostic factors determined by univariate and multivariate regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The nomogram for OS was developed by using four independent prognostic factors, including age, grade, T stage, and a number of examined lymph nodes. The C\u2010index of a nomogram for OS in DC and VC was 0.665 and 0.731, respectively. Calibration curves showed good consistency of the nomogram. The nomogram had a better accuracy in predicting OS compared with conventional staging system (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). On the basis of nomogram\u2010predicted scores, the patients were stratified into groups with different risk. The OS of low\u2010risk patients was significantly longer than high\u2010risk ones (<jats:italic>P<\/jats:italic>\u2009\u2264\u2009.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nomogram could be used to predict the OS of N0 AC. It could help guide further treatment in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25816","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T04:30:59Z","timestamp":1577421059000},"page":"518-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Development and validation of a nomogram for predicting overall survival of node\u2010negative ampullary carcinoma"],"prefix":"10.1002","volume":"121","author":[{"given":"Xi\u2010Tai","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pancreato\u2010Biliary Surgery, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Song","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pancreato\u2010Biliary Surgery, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 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