{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:12:52Z","timestamp":1793718772703,"version":"4.6.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Outcomes of palliative\u2010intent surgery in retroperitoneal sarcomas (RPS) are not well understood. This study aims to define indications for and outcomes after palliative\u2010intent RPS resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a retrospective 8\u2010institution database, patients undergoing resection of primary\/recurrent RPS with palliative intent were identified. Logistic regression and Cox\u2010proportional hazards models were constructed to analyze factors associated with postoperative complications and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 3088 patients, 70 underwent 87 palliative\u2010intent procedures. Most common indications were pain (26%) and bowel obstruction (21%). Dedifferentiated liposarcoma (n\u2009=\u200917, 24%), leiomyosarcoma (n\u2009=\u200913, 19%) were predominant subtypes. Median OS was 10.69 months (IQR, 3.91\u201023.23). R2 resection (OR, 8.60; CI, 1.42\u201052.15; <jats:italic>P<\/jats:italic>\u2009=\u2009.019), larger tumors (OR, 10.87; CI, 1.44\u201082.11; <jats:italic>P<\/jats:italic>\u2009=\u2009.021) and low preoperative albumin (OR, 0.14; CI, 0.04\u20100.57; <jats:italic>P<\/jats:italic>\u2009=\u2009.006) were associated with postoperative complications. Postoperative complications (HR, 1.95; CI, 1.02\u20103.71; <jats:italic>P<\/jats:italic>\u2009=\u2009.043) and high\u2010grade histology (HR, 6.56; CI, 1.72\u201025.05; <jats:italic>P<\/jats:italic>\u2009=\u2009.006) rather than resection status were associated with reduced OS. However, in R2\u2010resected patients, development of postoperative complications significantly reduced survival (<jats:italic>P<\/jats:italic>\u2009=\u2009.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postoperative complications and high\u2010grade histology rather than resection status impacts survival in palliative\u2010intent RPS resections. Given the higher incidence of postoperative complications which may diminish survival, palliative\u2010intent R2 resection should be offered only after cautious consideration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25890","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T14:06:46Z","timestamp":1584108406000},"page":"1140-1147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Outcomes of palliative\u2010intent surgery in retroperitoneal sarcoma\u2014Results from the US Sarcoma Collaborative"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-2109","authenticated-orcid":false,"given":"Sam Z.","family":"Thalji","sequence":"first","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-9961","authenticated-orcid":false,"given":"T. Clark","family":"Gamblin","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5229-961X","authenticated-orcid":false,"given":"Callisia","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Christians","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Charlson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia G.","family":"Ethun","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Winship Cancer Institute, Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Poultsides","sequence":"additional","affiliation":[{"name":"Department of Surgery Stanford University Medical Center  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie P.","family":"Grignol","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery The Ohio State University  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K.","family":"Roggin","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Chicago Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Votanopoulos","sequence":"additional","affiliation":[{"name":"Department of Surgery Wake Forest University  Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Surgery Washington University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-0734","authenticated-orcid":false,"given":"Daniel E.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-3269","authenticated-orcid":false,"given":"Kenneth","family":"Cardona","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Winship Cancer Institute, Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5743-1424","authenticated-orcid":false,"given":"Harveshp","family":"Mogal","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"other members of the US Sarcoma 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