{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:21:35Z","timestamp":1761294095227,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>After resection of colorectal liver metastases (CRLM), recurrent disease in the liver is a major cause of death but may be reduced with the addition of adjuvant hepatic arterial infusion (HAI) chemotherapy to systemic chemotherapy (SYS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigates organ\u2010specific causes of death in patients receiving adjuvant HAI and SYS compared to adjuvant SYS alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2000 and 2007, patients undergoing complete CRLM resection were identified from a prospectively maintained liver resection database and categorized as receiving HAI\u2009+\u2009SYS or SYS only. Using newly constructed definitions, mortality was attributed to specific organs (liver, lung, peritoneum, and brain) or infection. Univariate models and cumulative incidence functions were generated using competing risk methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 361 eligible patients, 208 (57.6%) received HAI\u2009+\u2009SYS and 153 (42.4%) received SYS. The median follow up among survivors was 142 months (range\u2009=\u200912\u2010217 months). Ten\u2010year overall survival was 50.6% in the HAI\u2009+\u2009SYS group compared to 30.9% in those receiving SYS (<jats:italic>P<\/jats:italic>\u2009=\u2009.004). The 5\u2010year cumulative incidence of liver\u2010related mortality was 6.8% in the HAI\u2009+\u2009SYS group compared to 14.3% in the SYS group (<jats:italic>P<\/jats:italic>\u2009=\u2009.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of HAI to SYS after CRLM resection is associated with a 50% reduction in liver\u2010related mortality at 5 years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25916","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T05:14:52Z","timestamp":1585718092000},"page":"1314-1319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Addition of adjuvant hepatic artery infusion to systemic chemotherapy following resection of colorectal liver metastases is associated with reduced liver\u2010related mortality"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1369-8212","authenticated-orcid":false,"given":"Rami","family":"Srouji","sequence":"first","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York City New York"},{"name":"Department of Surgery Washington University St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York City New York"},{"name":"Department of Surgery Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Boerner","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Buisman","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Seier","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithat","family":"Gonen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod P.","family":"Balachandran","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Drebin","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Jarnagin","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3359-3186","authenticated-orcid":false,"given":"T. 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