{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:50:45Z","timestamp":1774993845379,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>We classified the extent of mesenteric mass (MM) involvement that predicts challenging mesenteric lymph node dissection (mLND) by minimally invasive surgery (MIS) for ileal neuroendocrine tumors (i\u2010NETs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent surgery for i\u2010NETs were retrospectively reviewed. MM involvement was classified as region\u20100: no MM; region\u20101: &gt;2\u2009cm from the origins of the ileocolic artery\/vein; region\u20102: \u22642\u2009cm from the origins; and region\u20103: more proximal superior mesenteric artery\/vein. Logistic regression analysis was used to evaluate the predictive value of MM regions for gross positive mesenteric margin (mR2) and\/or conversion among the MIS cohort. The open surgery cohort was used as a reference for mR2 rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 108 patients, 83 patients (77%) underwent MIS. MMs in region\u20102 and region\u20103 were independent risk factors for mR2 and\/or conversion (odds ratio [95% confidence interval]: 4.25 [1.17\u201016.4] and 8.51\u2009\u00d7\u200910<jats:sup>7<\/jats:sup> [11.0\u2010], respectively, against regions\u20100 and 1]. mR2 rates of MIS and open surgery cohorts per region did not differ significantly (4% and 7% for regions\u20100 and 1; 17% and 25% for region\u20102; and 100% and 83% for region\u20103).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel stratification of MM regions was predictive of challenging mLND by MIS. Surgeons should have a low threshold for conversion for MMs in proximal regions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25930","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T05:28:17Z","timestamp":1586928497000},"page":"204-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A novel stratification of mesenteric mass involvement as a predictor of challenging mesenteric lymph node dissection by minimally invasive approach for ileal neuroendocrine tumors"],"prefix":"10.1002","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-6309","authenticated-orcid":false,"given":"Yosuke","family":"Kasai","sequence":"first","affiliation":[{"name":"Department of Surgery University of California, San Francisco  San Francisco California"},{"name":"UCSF Helen Diller Family Comprehensive Cancer Center  San Francisco 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