{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:13:31Z","timestamp":1768565611081,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030310541"],"award-info":[{"award-number":["2017A030310541"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The ligation of thoracic duct interrupts the normal lymphatic circulation. Whether the ligation of thoracic duct would affect tumor recurrence and patient survival is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The correlations between prophylactic thoracic duct ligation (PLG) and prognosis were examined in patients with esophageal squamous cell carcinoma. Patients who received Ivor Lewis or McKeown esophagectomy with systemic lymph node dissection and R0 resection between 2003 and 2013 in Sun Yat\u2010sen University Cancer Center were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total number of 473 and 462 were included in the PLG group and non\u2010prophylactic thoracic duct ligation (NPLG) group, respectively. The PLG group had a lower 5\u2010year survival rate (48.2% vs 61.6%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). After a 1:1 propensity score matching, 874 cases (437 pairs) were included and the survival analysis showed that PLG was associated with worse 5\u2010year cumulative survival of 48.6% vs 61.6% in those patients without ligation (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The multivariate analysis revealed that PLG was an independent factor for poor prognosis after esophagectomy (hazard ratio, HR\u2009=\u20091.56; 95% confidence interval, 95% CI, 1.26\u20101.93, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Additionally, PLG was associated with regional lymph node relapse (<jats:italic>P<\/jats:italic>\u2009=\u2009.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PLG should not be performed routinely if no sign of thoracic duct rupture or tumor invasion were identified.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25948","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T03:30:21Z","timestamp":1589513421000},"page":"336-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prophylactic thoracic duct ligation is associated with poor prognosis and regional lymph node relapse in esophageal squamous cell carcinoma"],"prefix":"10.1002","volume":"122","author":[{"given":"Jun\u2010Ying","family":"Chen","sequence":"first","affiliation":[{"name":"Guangdong Esophageal Cancer Institute  Guangzhou China"},{"name":"Department of Thoracic Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian\u2010Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Esophageal Cancer Institute  Guangzhou China"},{"name":"Department of Thoracic Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shui\u2010Shen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 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