{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:14:52Z","timestamp":1769922892250,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgery for perihilar cholangiocarcinoma (PHCC) is associated with high morbidity. This study aimed to investigate the clinical value of the future liver remnant volume\u2010to\u2010body weight (FLRV\/BW) and propose a risk score for predicting the risk of patients with PHCC developing posthepatectomy liver failure (PHLF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 348 patients who underwent major hepatectomy with bile duct resection for PHCC during 2008\u20102015 at a single center in Korea and they were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinically relevant PHLF was noted in 40 patients (11.4%). The area under the curve (AUC) for FLRV\/BW was not significantly different from that for FLRV\/total liver volume (<jats:italic>P<\/jats:italic>\u2009=\u2009.803) or indocyanine green clearance of the future liver remnant (<jats:italic>P<\/jats:italic>\u2009=\u2009.629) in terms of predicting PHLF. On multivariate analysis, predictors of PHLF (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) were male sex, albumin less than 3.5\u2009g\/dL, preoperative cholangitis, portal vein resection, FLRV\/BW less than 0.5%, and FLRV\/BW 0.5% to 0.75%. These variables were included in the risk score that showed good discrimination (AUC, 0.853; 95% CI, 0.802\u20100.904). It will help rank patients into three risk subgroups with a predicted liver failure incidence of 4.75%, 18.73%, and 51.58%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FLRV\/BW is a comparable risk prediction factor of PHLF and the proposed risk score can help to predict the risk of planned surgery in PHCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25974","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T05:21:47Z","timestamp":1589865707000},"page":"469-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Risk factors of posthepatectomy liver failure for perihilar cholangiocarcinoma"],"prefix":"10.1002","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-9641","authenticated-orcid":false,"given":"Jong W.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8532-9531","authenticated-orcid":false,"given":"Yejong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8119-6943","authenticated-orcid":false,"given":"Woohyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-4374","authenticated-orcid":false,"given":"Jaewoo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki B.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-038X","authenticated-orcid":false,"given":"Dae W.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul 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