{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:10:15Z","timestamp":1783469415245,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the short\u2010 and long\u2010term outcomes of patients undergoing pancreaticoduodenectomy (PD) for duodenal neuroendocrine tumors (dNETs) vs pancreatic neuroendocrine tumors (pNETs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients undergoing PD for dNETs or pNETs between 1997 and 2016 were identified from a multi\u2010institutional database. Overall survival (OS) and recurrence\u2010free survival (RFS) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 276 patients who underwent PD, 244 (88.4%) patients had a primary pNET, whereas 32 (11.6%) patients had a dNET. Following PD, postoperative morbidity and mortality were comparable. While the total number of lymph nodes examined was similar between the two groups (median, dNETs 15.0 vs pNETs 13.0; <jats:italic>P<\/jats:italic>=\u2009.648), patients with dNETs had a higher incidence of lymph node metastasis (LNM) (60.0% vs 38.2%; <jats:italic>P<\/jats:italic>\u2009=\u2009.022) and a larger number of metastatic nodes (median, 3.5 vs 2.0; <jats:italic>P<\/jats:italic>\u2009=\u2009.039). No differences in OS or RFS were noted among patients with dNETs vs pNETs in both unadjusted and adjusted analyses. Among patients who recurred after PD, patients with dNETs were more likely to recur early (within 2 years, 100% vs 49.2%; <jats:italic>P<\/jats:italic>\u2009=\u2009.029) and at an extrahepatic site (intrahepatic\u2010only recurrence, 20.0% vs 54.1%; <jats:italic>P<\/jats:italic>\u2009=\u20090.142) vs patients with pNETs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with dNETs and pNETs had a similar prognosis following PD. Data on differences in the incidence of LNM, as well as in recurrence time and patterns may help to inform the treatment of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25978","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T20:05:05Z","timestamp":1590782705000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical outcomes of patients with duodenal vs pancreatic neuroendocrine tumors following pancreatoduodenectomy"],"prefix":"10.1002","volume":"122","author":[{"given":"Ding\u2010Hui","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Institute of Advanced Surgical Technology and Engineering The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-7326","authenticated-orcid":false,"given":"Xu\u2010Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Institute of Advanced Surgical Technology and Engineering The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"Division of Surgical Oncology, Wexner Medical Center and James Comprehensive Cancer Center The Ohio State University  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra G.","family":"Lopez\u2010Aguiar","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Poultsides","sequence":"additional","affiliation":[{"name":"Department of Surgery Stanford University  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virginia Mason Medical Center University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine and Public Health University of Wisconsin  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine Washington University  St Louis Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Idrees","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Vanderbilt University  Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Hepatopancreatobiliary and Advanced Gastrointestinal Surgery, Department of Surgery University of Michigan  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaya","family":"Spolverato","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir K.","family":"Maithel","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Wexner Medical Center and James Comprehensive Cancer Center The Ohio State University  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/MPA.0000000000001005","article-title":"Long\u2010term outcomes of gastroenteropancreatic neuroendocrine tumors","volume":"47","author":"Chi W","year":"2018","journal-title":"Pancreas"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.047"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.01.002"},{"key":"e_1_2_7_7_1","first-page":"138","article-title":"Gastroduodenal neuroendocrine neoplasms, including gastrinoma\u2014management guidelines (recommended by the Polish Network of Neuroendocrine Tumours)","volume":"68","author":"Lipi\u0144ski M","year":"2017","journal-title":"Endokrynol Pol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-012-0951-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2010.12.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.03.042"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443168"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3448-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25753"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6673-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2013.02.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.08.015"},{"key":"e_1_2_7_17_1","volume-title":"American Joint Committee on Cancer","author":"Amin MB","year":"2017"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs208"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-014-2456-x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-016-1537-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-016-3135-x"},{"key":"e_1_2_7_22_1","first-page":"1","article-title":"New nodal staging for primary pancreatic neuroendocrine tumors: a multi\u2010institutional and national data analysis","author":"Zhang XF","year":"2019","journal-title":"Ann Surg"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.03.005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000348"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.06.003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6260-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2018.1468479"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481408000836"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.016"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2019.05.020"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.25978","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T19:54:42Z","timestamp":1693770882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/jso.25978"],"URL":"https:\/\/doi.org\/10.1002\/jso.25978","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,29]]},"assertion":[{"value":"2020-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}