{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:25:59Z","timestamp":1784204759001,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>It is unclear if a specific strategy for simultaneous treatment of primary thymic neoplasms and pleural metastases confers benefit for Masaoka stage IVA disease. We reviewed our experience with thymic neoplasms with concurrent pleural metastases to identify factors influencing outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of patients who presented with stage IVA thymic neoplasms from 2000 to\u00a02018 were assessed. Multivariate Cox proportional hazards analyses were completed to determine predictors of progression\u2010free and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight patients were identified, including 34 (71%) who underwent surgery. Median overall and progression\u2010free survival were 123 and 21 months, respectively. The extent of resection varied, and was most commonly thymectomy plus partial pleurectomy (22, 65%). Median progression\u2010free survival for patients who underwent surgical resection versus those who had not was 24 versus 12 months (<jats:italic>P<\/jats:italic>\u2009=\u2009.018). Following surgical resection, mediastinal recurrence was uncommon (2, 6%, vs 7, 50% nonoperatively). Five\u2010year survival rates in these groups were suggestive of possible benefit to surgery (87% vs 68%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thymic neoplasms with pleural dissemination represents a treatment challenge. As part of a multidisciplinary approach, surgery appears to be associated with more favorable long\u2010term results, although selection bias may account for some of the survival differences observed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25981","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T04:11:28Z","timestamp":1590725488000},"page":"515-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Importance of resection for locoregional disease control in Masaoka stage IVA thymic neoplasms"],"prefix":"10.1002","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-0244","authenticated-orcid":false,"given":"Erin M.","family":"Corsini","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle G.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne L.","family":"Hofstetter","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza J.","family":"Mehran","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Sepesi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Swisher","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ara A.","family":"Vaporciyan","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett L.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara B.","family":"Antonoff","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.05.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu210"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-018-0859-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.255307"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"LeeHS JangHJ LoEM et al.Povidone\u2010iodine results in rapid killing of thymic epithelial tumour cells through cellular fixation.Interact Cardiovasc Thorac Surg.2018.","DOI":"10.1093\/icvts\/ivy248"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0069-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.01.042"},{"key":"e_1_2_8_9_1","unstructured":"NCCN.NCCN guidelines version 1 \u00a02020. 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