{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:41:06Z","timestamp":1768516866745,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With the approval of adjuvant therapy for stage III melanoma, accurate staging is more important than ever. Sentinel node biopsy (SNB) is an accurate staging tool, yet the presence of capsular nevi (CN) can lead to a false\u2010positive diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Retrospective analysis of the American Joint Committee on Cancer 7th edition stage IIIA melanoma patients who were treated at our institute between 2000 and 2015. SNB slides were reviewed for this study by an expert melanoma pathologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 159 eligible patients, 14 originally diagnosed with metastatic melanoma merely had CN (8.8%). Another two merely had melanophages (1.3%). Thus, 10.1% of SNs were considered false positive after revision. In 12 patients, the SN tumor burden was originally reported as larger than 1\u2009mm but turned out to be less than 1\u2009mm. Four patients originally reported as SN tumor burden less than 1\u2009mm before revision turned out to have larger than 1\u2009mm. These patients might have been over\u2010 or undertreated in the current era of adjuvant therapy for stage III melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Distinguishing metastatic melanoma from benign CN and melanophages can be a diagnostic challenge. We plead for an expert pathologists' review, especially when using the SNB\u2009+\u2009results to determine treatment consequences.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26095","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T05:27:59Z","timestamp":1593494879000},"page":"964-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Challenges in sentinel node pathology in the era of adjuvant treatment"],"prefix":"10.1002","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0703-5092","authenticated-orcid":false,"given":"Viola","family":"Franke","sequence":"first","affiliation":[{"name":"Departments of Surgical Oncology Netherlands Cancer Institute \u2010 Antoni van Leeuwenhoek  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6218-1589","authenticated-orcid":false,"given":"Max F.","family":"Madu","sequence":"additional","affiliation":[{"name":"Departments of Surgical Oncology Netherlands Cancer Institute \u2010 Antoni van Leeuwenhoek  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolien","family":"Bierman","sequence":"additional","affiliation":[{"name":"Division of Pathology Netherlands Cancer Institute \u2010 Antoni van Leeuwenhoek  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem M. 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