{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:28:44Z","timestamp":1787819324386,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T00:00:00Z","timestamp":1595030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702549"],"award-info":[{"award-number":["81702549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8197101783"],"award-info":[{"award-number":["8197101783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the association between different metastatic sites and survival in endometrial cancer (EC) patients with International Federation of Gynecology and Obstetrics (FIGO) stage IVB disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FIGO stage IVB patients with EC were selected from the surveillance, epidemiology, and end results\u00a0database. Overall survival (OS) and cause\u2010specific survival (CSS) were analyzed with Kaplan\u2010Meier analysis and log\u2010rank tests. Univariate and multivariate Cox proportional hazard models were used to identify the prognostic factors for OS and CSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 929 FIGO stage IVB patients with EC were identified. Patients with peritoneum metastasis were associated with significantly better OS and CSS compared to those with organ\u2010specific metastasis (median OS: 29 vs 19 months, <jats:italic>P<\/jats:italic>\u2009=\u2009.005; median CSS: 47 vs 25 months, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Moreover, the survival superiority of peritoneum metastasis remained significant when organ\u2010specific metastasis was further classified into specific single\u2010organ metastasis. The multivariate analysis also indicated that compared with peritoneum metastasis, bone, brain, and lung metastasis were independent prognostic factors for worse OS. Similarly, distant lymph node, bone, brain, liver, and lung metastasis were associated with worse CSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Metastatic sites affected prognosis in FIGO stage IVB patients with EC. Patients with peritoneum metastasis had significantly better survival outcomes than those with organ\u2010specific metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26102","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T21:34:06Z","timestamp":1595108046000},"page":"941-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic value of different metastatic sites for patients with FIGO stage IVB endometrial cancer after surgery: A\u00a0SEER database analysis"],"prefix":"10.1002","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6214-8308","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoliang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou 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