{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:27:07Z","timestamp":1740104827626,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Tumor location (peritoneal vs hepatic) has been incorporated in the 8th edition of the American Joint Committee on Cancer Staging system for gallbladder cancer. However, larger studies are needed to confirm the prognostic impact of tumor location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with pathologically\u2010confirmed gallbladder cancer with information on primary tumor location were included from the National Cancer Database (2009\u20102012). We compared patients with hepatic\u2010side tumors to those on the peritoneal side. Survival data were plotted using the Kaplan\u2010Meier method. Prognostic factors were modeled with a multivariate Cox Proportional Hazards Model. Primary outcome was overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1251 patients were included. In comparison to patients with peritoneal\u2010sided tumors, patients with hepatic\u2010sided tumors were more likely to: be of higher pT stage (pT3: 49% vs 24%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001); node positive (31% vs 24%; <jats:italic>P<\/jats:italic>\u2009=\u2009.016); undergo liver resection (53% vs 25%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001); or have positive margins (29% vs 16%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). However, on multivariate analysis, there was no difference in OS between the groups (HR, 0.97; 95% CI, 0.79\u20101.18; <jats:italic>P<\/jats:italic>\u2009=\u2009.753). Liver resection was associated with improved survival regardless of tumor location in pT2 tumors (peritoneal: HR, 0.57; <jats:italic>P<\/jats:italic>\u2009=\u2009.034; hepatic: HR, 0.67; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study failed to demonstrate the independent prognostic value of primary tumor location in patients with gallbladder cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26107","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T21:36:51Z","timestamp":1594503411000},"page":"1084-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prognostic impact of tumor location in resected gallbladder cancer: A national cohort 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California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byrne","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Stanford Medicine Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Surgery City of Hope National Medical Center Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-9959","authenticated-orcid":false,"given":"Yuman","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Surgery City of Hope National Medical Center Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-2226","authenticated-orcid":false,"given":"Mustafa","family":"Raoof","sequence":"additional","affiliation":[{"name":"Department of Surgery City of Hope National Medical Center Duarte 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