{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:11:11Z","timestamp":1768777871953,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Platon Foundation, University of Nebraska Foundation","award":["01125970"],"award-info":[{"award-number":["01125970"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Outcomes for gastrointestinal peritoneal metastases (GI\u2010PM) are worse compared to systemic metastases, with a paucity of data exploring extended mutation profiling. An exploratory mutation analysis in GI\u2010PMs was performed as a \u201cproof of concept\u201d of potential predictive values of profiling in GI\u2010PM and rates of actionable mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 40 GI\u2010PM patients: 14 low\u2010grade mucinous carcinoma peritonei and 26 HG\u2010PM (12 colons, 10 appendix, 4 small bowels). Demographics, histologies, peritoneal cancer indexes, cytoreduction scores, and survival data were collected. NGS 50\u2010gene mutation profiling was performed on 38 specimens. The association of mutations with survival was evaluated in high\u2010grade PM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>KRAS, TP53, and SMAD4 mutations were observed in 61%, 29%, and 8% of cases across all tumor histologies. In 66% cases &gt;1 mutations occurred, associated with decreased survival in HG\u2010PM: 32 vs 73 months, <jats:italic>P<\/jats:italic>\u2009=\u2009.03. TP53 or SMAD4 mutations were associated with decreased survival in HG\u2010PM: 22 vs 48 months, <jats:italic>P<\/jats:italic>\u2009=\u2009.02. Actionable mutations were detected in 70%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Actionable mutations were detected at high rates. GI\u2010PMs have similar mutational profiles and TP53, SMAD4, and\/or &gt;1 mutation were associate with decreased survival in HG\u2010PM. This data supports the concept of the extended mutation profiling utility in GI\u2010PM warranting further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26114","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T03:51:28Z","timestamp":1594698688000},"page":"1106-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigating the utility of extended mutation analysis in gastrointestinal peritoneal metastasis"],"prefix":"10.1002","volume":"122","author":[{"given":"Jason M.","family":"Foster","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asish","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6622-3958","authenticated-orcid":false,"given":"Chunmeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Shostrom","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison M.","family":"Cushman\u2010Vokoun","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7166"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4147-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2241-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3145-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.187"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.09.017"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.7160"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6369-x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.6847"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2018.07.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-5938-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70330-4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.5091"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5469"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2018.05.012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5361-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002367"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5609-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.100"},{"key":"e_1_2_8_22_1","unstructured":"American Society of Clinical Oncology (ASCO). 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