{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:30:38Z","timestamp":1783481438770,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hepatic artery infusion pump (HAIP) chemotherapy is a specialized therapy for patients with unresectable colorectal liver metastases (uCRLM). Its effectiveness was demonstrated from a high volume center, with uncertainty regarding the feasibility and safety at other centers. Therefore, we sought to assess the safety and feasibility of HAIP for the management of uCRLM at other centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter retrospective cohort study of patients with uCRLM treated with HAIP from January 2003 to December 2017 at six North American centers initiating the HAIP program. Outcomes included the safety and feasibility of HAIP chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 154 patients with HAIP insertion and the median age of 54 (48\u201361) years. The burden of disease was &gt;10 intra\u2010hepatic metastatic foci in 59 (38.3%) patients. Patients received at least one cycle of systemic chemotherapy before HAIP insertion. Major complications occurred in 7 (4.6%) patients during their hospitalization and 13 (8.4%) patients developed biliary sclerosis during follow\u2010up. A total of 148 patients (96.1%) received at least one\u2010dose of HAIP chemotherapy with a median of 5 (4\u20137) cycles. 78 patients (56.5%) had a complete or partial response and 12 (7.8%) received a curative liver resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HAIP programs can be safely and effectively initiated in previously inexperienced centers with good response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26270","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T19:34:40Z","timestamp":1603481680000},"page":"252-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Safety and feasibility of initiating a hepatic artery infusion pump chemotherapy program for unresectable colorectal liver metastases: A multicenter, retrospective cohort study"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9721-2808","authenticated-orcid":false,"given":"Hala","family":"Muaddi","sequence":"first","affiliation":[{"name":"Division of General Surgery Sunnybrook Health Science Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"D'Angelica","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6585-8046","authenticated-orcid":false,"given":"Jason T.","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Arthur G. 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James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Latchana","sequence":"additional","affiliation":[{"name":"Department of Surgery Novant Health Carolina Surgical Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Roke","sequence":"additional","affiliation":[{"name":"Division of General Surgery Sunnybrook Health Science Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Joung","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of General Surgery Sunnybrook Health Science Centre Toronto Ontario Canada"},{"name":"St Michael's Hospital University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Carpizo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Rochester's School of Medicine and Dentistry and Wilmot Cancer Center Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Spencer","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Rutgers Cancer Institute of New Jersey New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Surgery Washington University School of Medicine and the Alvin J. 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