{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:10:46Z","timestamp":1759133446241},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate treatment strategies and factors influencing overall survival (OS) and disease\u2010free survival (DFS) in resectable, non\u2013small cell lung cancer (NSCLC) with mediastinal (N2) lymph node metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients undergoing surgery for NSCLC with N2 disease between 2006 and 2016 were included. Treatment approaches included surgery only, neoadjuvant therapy followed by surgery, surgery followed by adjuvant therapy, and neoadjuvant therapy followed by surgery and adjuvant therapy (triple therapy). Patient clinical and pathologic data were retrospectively collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 281 patients were included in the study. In total, 209 patients had neoadjuvant therapy, 47.4% of which went on to received additional adjuvant therapy. The pathologic complete response rate was 12.9%. The treatment strategy which included triple therapy was isolated as a significant contributor to improved OS and DFS. Nodal downstaging (N0) after induction therapy conferred an OS benefit (38.3% vs. 15.6%, <jats:italic>p<\/jats:italic>\u2009=\u2009.03). Patients with single\u2010station N2 disease experienced higher DFS. Video\u2010assisted thoracic surgery (VATS) lobectomy completion rates were higher at the end of the study period compared to the beginning (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients who undergo neoadjuvant therapy for N2\u2010positive NSCLC may benefit from additional adjuvant therapy. Single\u2010station N2 disease confers higher DFS. VATS completion rates for lobectomy increase as experience increases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26305","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T23:46:27Z","timestamp":1606866387000},"page":"579-586","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adjuvant therapy following induction therapy and surgery improves survival in N2\u2010positive non\u2013small cell lung cancer"],"prefix":"10.1002","volume":"123","author":[{"given":"Abby A.","family":"White","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel N.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Division of Biostatistcs, Department of Data Sciences Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suden","family":"Kucukak","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Polhemus","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Jaklitsch","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Mentzer","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon O.","family":"Wee","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Bueno","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott J.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Surveillance Epidemiology and End Results (SEER). 2018. Bethesda MD: US National Institutes of Health National Cancer Institute."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5753"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401203300301"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.9.673"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60737-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.04.088"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01585-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20644"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.07.033"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.16.2981"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.26305","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T13:20:48Z","timestamp":1693747248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.26305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/jso.26305"],"URL":"https:\/\/doi.org\/10.1002\/jso.26305","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2020-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}