{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:25:58Z","timestamp":1785331558433,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The PERISCOPE I (Treatment of PERItoneal dissemination in Stomach Cancer patients with cytOreductive surgery and hyPErthermic intraperitoneal chemotherapy) study was conducted to investigate the safety and feasibility of hyperthermic intraperitoneal chemotherapy (HIPEC) in gastric cancer patients with limited peritoneal dissemination. In this\u00a0study, tumor characteristics and clinical outcome of the patients treated in the PERISCOPE I trial were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who had undergone the full study protocol were selected; that is, preoperative systemic chemotherapy, followed by a surgical procedure consisting of a (sub)total gastrectomy, cytoreductive surgery, and HIPEC with oxaliplatin (460\u2009mg\/m<jats:sup>2<\/jats:sup>) and docetaxel (in escalating doses).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five PERISCOPE I patients underwent the full study protocol. Most patients had an ypT3\u20104 tumor (96%) and the diffuse\u2010type histology was predominant (64%). Seven patients (28%) had a microscopically irradical (R1) resection. In all patients, a complete cytoreduction was achieved. Median follow\u2010up was 37 (95% confidence interval [CI]: 34\u201339) months. Disease recurrence was detected in 17 patients (68%). Median disease\u2010free and overall survival were 12 and 15 months, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this series of gastric cancer patients with limited peritoneal dissemination who underwent HIPEC surgery, unfavorable tumor characteristics were common. Survival might be encouraging but disease recurrence was frequent. The efficacy of an HIPEC procedure in improving prognosis is currently being investigated in the PERISCOPE II trial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26366","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:28:40Z","timestamp":1610692120000},"page":"904-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Tumor characteristics and clinical outcome of peritoneal metastasis of gastric origin treated with a hyperthermic intraperitoneal chemotherapy procedure in the PERISCOPE I trial"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-081X","authenticated-orcid":false,"given":"Willem\u00a0J.","family":"Koemans","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, the Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa\u00a0T.","family":"van der Kaaij","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, the Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma\u00a0C. E.","family":"Wassenaar","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila","family":"Boerma","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Boot","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, the Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Sikorska","sequence":"additional","affiliation":[{"name":"Department of Biometrics, the Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje","family":"Los","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Grootscholten","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, the Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen\u00a0J.","family":"Hartemink","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, the Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander\u00a0A. 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