{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:12:23Z","timestamp":1790651543868,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC) is predominantly performed and studied in academic centers. While developing CRS\/HIPEC programs in nonacademic hospitals can increase accessibility, its safety and oncological efficacy remains unclear. We evaluated CRS\/HIPEC outcomes in a nonacademic setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center descriptive study was conducted using a prospective database. Data of all CRS\/HIPEC attempts in peritoneal surface malignancies (PSM) patients from October 1994 to November 2019 were extracted. Surgical and survival outcomes were measured. Center experience was assessed by quartiles of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 856 patients underwent 948 CRS\/HIPEC attempts: 788 (83%) completed CRS\/HIPECs, 144 (15%) aborted HIPECs, and 16 (2%) complete cytoreductions (CC\u20100\/1) without chemoperfusion. For completed CRS\/HIPECs, median peritoneal cancer index was 24 (interquartile range: 10\u201333) and CC\u20100\/1 rate was 88%. Major complications occurred in 23.5% with 30\u2010 and 100\u2010day mortality of 1.0% and 2.3%, respectively. Median overall survival was 68 months (95% confidence interval [CI]: 50\u201386). Median progression\u2010free survival was 37 months (95%CI: 28\u201346). Incomplete cytoreduction and major complication rates decreased over time, while mortality remained low and constant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CRS\/HIPEC at a nonacademic center with advanced surgical and auxiliary services is a safe option to treat PSM with favorable surgical and oncological outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26371","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T04:37:25Z","timestamp":1612327045000},"page":"1030-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Surgical and oncological outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy at a nonacademic center: 25\u2010year experience"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4772-5477","authenticated-orcid":false,"given":"Andrei","family":"Nikiforchin","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Mercy Medical Center, The Institute for Cancer Care at Mercy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-5660","authenticated-orcid":false,"given":"Vadim","family":"Gushchin","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Mercy Medical Center, The Institute for Cancer Care at Mercy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-3827","authenticated-orcid":false,"given":"Mary Caitlin","family":"King","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Mercy Medical Center, The Institute for Cancer Care at Mercy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-6547","authenticated-orcid":false,"given":"Ekaterina","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Mercy Medical Center, The Institute for Cancer Care at Mercy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-5278","authenticated-orcid":false,"given":"Carol","family":"Nieroda","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Mercy Medical Center, The Institute for Cancer Care at Mercy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2641-1564","authenticated-orcid":false,"given":"Michelle","family":"Sittig","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Mercy Medical Center, The Institute for Cancer Care at Mercy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4132-9489","authenticated-orcid":false,"given":"Armando","family":"Sardi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Mercy Medical Center, The Institute for Cancer Care at Mercy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199502000-00002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9966-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21054"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13593"},{"issue":"6","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jogoh.2019.03.018","article-title":"Management of epithelial cancer of the ovary, fallopian tube, primary peritoneum. 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