{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:47:27Z","timestamp":1785476847586,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is increasingly accepted as the best therapeutic option in primary and some secondary peritoneal malignancies. The ramifications of this procedure on fertility are unknown. The aim of this study was to assess the current association of CRS\/HIPEC with fertility following surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A review of patients who underwent CRS\/HIPEC between 2009 and 2018 was performed. Female patients were included if they were between ages 18\u201350 at the time of surgery. Gynecologic and obstetric history before and following CRS\/HIPEC was collected by phone interview.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 48 eligible participants, 21 completed the survey. Sixty\u2010five percent of women underwent a total abdominal hysterectomy before or during CRS. Twenty\u2010nine percent of these women recall fertility counseling before CRS\/HIPEC, while 14.3% saw a fertility specialist for consultation, and only one patient proceeded with oocyte cryopreservation before treatment. There were no pregnancies reported following treatment with CRS\/HIPEC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Few patients after CRS\/HIPEC retain child\u2010bearing potential, partly due to the high rate of hysterectomy and oophorectomy at time of surgery. Efforts towards improved preoperative counseling, increased oocyte cryopreservation, and evaluating the safety of preserving reproductive organs at the time of surgery are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26387","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T18:46:08Z","timestamp":1611686768000},"page":"1045-1049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fertility after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A call to action"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2240-3826","authenticated-orcid":false,"given":"Caroline","family":"Violette","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Southern California\/LAC+USC  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesia","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Shandley","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-839X","authenticated-orcid":false,"given":"Rachel","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Staley","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Winer","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir","family":"Maithel","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Hipp","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kawwass","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-6992","authenticated-orcid":false,"given":"Maria","family":"Russell","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23749"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"143","article-title":"Cytoreductive surgery and intraperitoneal chemotherapy: an evidence\u2010based review\u2010past, present and future","volume":"7","author":"Dehal A","year":"2016","journal-title":"J Gastrointest Oncol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.06.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1595-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.08.045"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21457"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.09.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.1914"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.05.034"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-2879-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.03.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.11.018"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex276"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2016.0072"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex257"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-720X.2010.00536.x"},{"issue":"4","key":"e_1_2_6_18_1","first-page":"352","article-title":"Ovarian response after random\u2010start controlled ovarian stimulation to cryopreserve oocytes in cancer patients","volume":"22","author":"Campos APC","year":"2018","journal-title":"JBRA Assist Reprod"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.26387","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T21:19:02Z","timestamp":1693689542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.26387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/jso.26387"],"URL":"https:\/\/doi.org\/10.1002\/jso.26387","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,26]]},"assertion":[{"value":"2020-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}