{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:56:55Z","timestamp":1787500615448,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Appendiceal cancers represent a diverse group of malignancies with varying biological behavior. The significance of lymph node metastases in relation to long\u2010term survival and chemotherapy response is poorly defined.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The National Cancer Database was queried to find patients diagnosed with appendiceal cancer from 1998 to 2012. Kaplan\u2013Meier curves and multivariable Cox regression analyses were used to study the association between lymph node status and overall survival. Stage IV patients were excluded.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The rate of nodal positivity of the 9841 patients with known node status was: signet ring 47.4%, carcinoid 42.3%, nonmucinous adenocarcinoma 28.8%, goblet cell 21.9%, and mucinous adenocarcinoma 20.4%. Node\u2010positive patients had worse long\u2010term survival for all subtypes with the exception of carcinoid tumors (\n p<\/jats:italic>\n \u2009<\u20090.001). The strongest association was for signet cell and goblet cell. Adjuvant chemotherapy in node\u2010positive patients improved survival for mucinous, nonmucinous, and signet ring cell histology (\n p<\/jats:italic>\n \u2009<\u20090.01), but not for goblet cell.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Nodal involvement in patients with appendiceal cancer varies in incidence, association with adverse survival, and response to systemic therapy. Individualized treatment algorithms for the management of the subtypes of appendiceal cancer are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jso.26493","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T17:19:26Z","timestamp":1619457566000},"page":"88-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lymph node positivity and association with long\u2010term survival for different histologies of appendiceal cancer"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-2250","authenticated-orcid":false,"given":"Christopher","family":"Webb","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Mayo Clinic Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hui","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Surgical Outcomes Program Mayo Clinic Arizona USA"},{"name":"Department of Biostatistics Mayo Clinic Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Pockaj","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Mayo Clinic Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Gray","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Mayo Clinic Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Chee","family":"Stucky","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Mayo Clinic Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-6766","authenticated-orcid":false,"given":"Nabil","family":"Wasif","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Mayo Clinic Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-014-2726-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000535"},{"key":"e_1_2_8_4_1","volume-title":"World Health Organization International Classification of Diseases for Oncology","author":"Percy C","year":"1990"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0196-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29744"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-016-3148-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2238-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10589"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21888"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0774-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6462-1"},{"key":"e_1_2_8_13_1","unstructured":"National Cancer Database.https:\/\/www.facs.org\/quality-programs\/cancer\/ncdb. 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